Enhanced production of recombinant B-domain deleted factor VIII from Chinese hamster ovary cells by propionic and butyric acids

Bok Hwan Chun; Song Yong Park; Namhyun Chung; Won Gi Bang

doi:10.1023/A:1022301528118

Enhanced production of recombinant B-domain deleted factor VIII from Chinese hamster ovary cells by propionic and butyric acids

Bok Hwan Chun, Song Yong Park, Namhyun Chung, Won Gi Bang

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Sodium propionate, as well as sodium butyrate, enhanced the production of recombinant B-domain-deleted, factor VIII (rFVIIIdB) by Chinese hamster ovary cells growing in a spinner-flask with a protein-free medium by more than six-fold. The two acids, however, had different cytotoxicities.

Original language	English
Pages (from-to)	315-319
Number of pages	5
Journal	Biotechnology letters
Volume	25
Issue number	4
DOIs	https://doi.org/10.1023/A:1022301528118
Publication status	Published - 2003 Feb

Keywords

Alkanoic acid
Factor VIII
Protein-free medium
Sodium butyrate
Sodium propionate

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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10.1023/A:1022301528118

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title = "Enhanced production of recombinant B-domain deleted factor VIII from Chinese hamster ovary cells by propionic and butyric acids",

abstract = "Sodium propionate, as well as sodium butyrate, enhanced the production of recombinant B-domain-deleted, factor VIII (rFVIIIdB) by Chinese hamster ovary cells growing in a spinner-flask with a protein-free medium by more than six-fold. The two acids, however, had different cytotoxicities.",

keywords = "Alkanoic acid, Factor VIII, Protein-free medium, Sodium butyrate, Sodium propionate",

author = "Chun, {Bok Hwan} and Park, {Song Yong} and Namhyun Chung and Bang, {Won Gi}",

note = "Funding Information: This work was supported by a research fund from the Green Cross Corp.",

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T1 - Enhanced production of recombinant B-domain deleted factor VIII from Chinese hamster ovary cells by propionic and butyric acids

AU - Chun, Bok Hwan

AU - Park, Song Yong

AU - Chung, Namhyun

AU - Bang, Won Gi

N1 - Funding Information: This work was supported by a research fund from the Green Cross Corp.

PY - 2003/2

Y1 - 2003/2

N2 - Sodium propionate, as well as sodium butyrate, enhanced the production of recombinant B-domain-deleted, factor VIII (rFVIIIdB) by Chinese hamster ovary cells growing in a spinner-flask with a protein-free medium by more than six-fold. The two acids, however, had different cytotoxicities.

AB - Sodium propionate, as well as sodium butyrate, enhanced the production of recombinant B-domain-deleted, factor VIII (rFVIIIdB) by Chinese hamster ovary cells growing in a spinner-flask with a protein-free medium by more than six-fold. The two acids, however, had different cytotoxicities.

KW - Alkanoic acid

KW - Factor VIII

KW - Protein-free medium

KW - Sodium butyrate

KW - Sodium propionate

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U2 - 10.1023/A:1022301528118

DO - 10.1023/A:1022301528118

M3 - Article

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AN - SCOPUS:0242417625

SN - 0141-5492

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SP - 315

EP - 319

JO - Biotechnology letters

JF - Biotechnology letters

IS - 4

ER -

Enhanced production of recombinant B-domain deleted factor VIII from Chinese hamster ovary cells by propionic and butyric acids

Abstract

Keywords

ASJC Scopus subject areas

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