Enhanced production of recombinant B-domain deleted factor VIII from Chinese hamster ovary cells by propionic and butyric acids

Bok Hwan Chun; Song Yong Park; Namhyun Chung; Won Gi Bang

doi:10.1023/A:1022301528118

Enhanced production of recombinant B-domain deleted factor VIII from Chinese hamster ovary cells by propionic and butyric acids

Bok Hwan Chun, Song Yong Park, Namhyun Chung, Won Gi Bang

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Sodium propionate, as well as sodium butyrate, enhanced the production of recombinant B-domain-deleted, factor VIII (rFVIIIdB) by Chinese hamster ovary cells growing in a spinner-flask with a protein-free medium by more than six-fold. The two acids, however, had different cytotoxicities.

Original language	English
Pages (from-to)	315-319
Number of pages	5
Journal	Biotechnology letters
Volume	25
Issue number	4
DOIs	https://doi.org/10.1023/A:1022301528118
Publication status	Published - 2003 Feb

Bibliographical note

Funding Information:
This work was supported by a research fund from the Green Cross Corp.

Keywords

Alkanoic acid
Factor VIII
Protein-free medium
Sodium butyrate
Sodium propionate

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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10.1023/A:1022301528118

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abstract = "Sodium propionate, as well as sodium butyrate, enhanced the production of recombinant B-domain-deleted, factor VIII (rFVIIIdB) by Chinese hamster ovary cells growing in a spinner-flask with a protein-free medium by more than six-fold. The two acids, however, had different cytotoxicities.",

keywords = "Alkanoic acid, Factor VIII, Protein-free medium, Sodium butyrate, Sodium propionate",

author = "Chun, {Bok Hwan} and Park, {Song Yong} and Namhyun Chung and Bang, {Won Gi}",

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AU - Chun, Bok Hwan

AU - Park, Song Yong

AU - Chung, Namhyun

AU - Bang, Won Gi

N1 - Funding Information: This work was supported by a research fund from the Green Cross Corp.

PY - 2003/2

Y1 - 2003/2

N2 - Sodium propionate, as well as sodium butyrate, enhanced the production of recombinant B-domain-deleted, factor VIII (rFVIIIdB) by Chinese hamster ovary cells growing in a spinner-flask with a protein-free medium by more than six-fold. The two acids, however, had different cytotoxicities.

AB - Sodium propionate, as well as sodium butyrate, enhanced the production of recombinant B-domain-deleted, factor VIII (rFVIIIdB) by Chinese hamster ovary cells growing in a spinner-flask with a protein-free medium by more than six-fold. The two acids, however, had different cytotoxicities.

KW - Alkanoic acid

KW - Factor VIII

KW - Protein-free medium

KW - Sodium butyrate

KW - Sodium propionate

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U2 - 10.1023/A:1022301528118

DO - 10.1023/A:1022301528118

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JO - Biotechnology letters

JF - Biotechnology letters

IS - 4

ER -

Enhanced production of recombinant B-domain deleted factor VIII from Chinese hamster ovary cells by propionic and butyric acids

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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