Enhanced production of recombinant B-domain deleted factor VIII from Chinese hamster ovary cells by propionic and butyric acids

Bok Hwan Chun, Song Yong Park, Namhyun Chung, Won Gi Bang

    Research output: Contribution to journalArticlepeer-review

    24 Citations (Scopus)

    Abstract

    Sodium propionate, as well as sodium butyrate, enhanced the production of recombinant B-domain-deleted, factor VIII (rFVIIIdB) by Chinese hamster ovary cells growing in a spinner-flask with a protein-free medium by more than six-fold. The two acids, however, had different cytotoxicities.

    Original languageEnglish
    Pages (from-to)315-319
    Number of pages5
    JournalBiotechnology letters
    Volume25
    Issue number4
    DOIs
    Publication statusPublished - 2003 Feb

    Bibliographical note

    Funding Information:
    This work was supported by a research fund from the Green Cross Corp.

    Keywords

    • Alkanoic acid
    • Factor VIII
    • Protein-free medium
    • Sodium butyrate
    • Sodium propionate

    ASJC Scopus subject areas

    • Biotechnology
    • Bioengineering
    • Applied Microbiology and Biotechnology

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