Enhanced proliferation of rabbit chondrocytes by using a well circulated nanoshock system

Sitansu Sekhar Nanda, Tuntun Wang, Hong Yeol Yoon, Seong Soo A. An, K. P.S.S. Hembram, Kwangmeyung Kim, Dong Kee Yi

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The gold nanorods (GNRs) embedded alginate-chitosan (scaffold), which was designed and fabricated to produce efficient handling of the cell proliferations. Scaffold embedded GNR (SGNR) and NIR (near infrared) irradiations are developing into an interesting medical prognosis tool for rabbit chondrocyte (RC) proliferation. SGNR contained a pattern of uniform pores. Biocompatibility and cellular proliferation achieved by disclosures to NIR irradiations, providing high cell survival. SGNR and NIR irradiations could produce mechanical and biochemical cues for regulating RCs proliferations. To determine the thermal stress, it exposed RCs to 39–42 °C for 0–240 min at the start point of the cell culture cycle. It produced photothermal stress in cellular surrounding (cells located adjacent to and within scaffold) and it deals with the proliferation behavior of RC. All the processes were modeled with experimental criteria and time evolution process. Our system could help the cell proliferation by generating heat for cells. Hence, the present strategy could be implemented for supporting cell therapeutics after transplantation. This implementation would open new design techniques for integrating the interfaces between NIR irradiated and non-irradiated tissues.

Original languageEnglish
Article number19388
JournalScientific reports
Issue number1
Publication statusPublished - 2021 Dec

Bibliographical note

Funding Information:
This work was supported by the Korean National Research Foundation (NRF-2021R1F1A1048388) and the intramural research program of KIST.

Publisher Copyright:
© 2021, The Author(s).

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Enhanced proliferation of rabbit chondrocytes by using a well circulated nanoshock system'. Together they form a unique fingerprint.

Cite this