Enhancement of exercise endurance capacity by fermented deer antler in BALB/c mice

Seongho Jang, Eu Ddeum Park, Hyung Joo Suh, Sang Hun Lee, Jin Soo Kim, Yooheon Park

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


To investigate the activity of fermented deer antler on exercise endurance capacity, we evaluated endurance capacity in five-week-old male BALB/c mice by administering the fermented deer antler extract (FA) or the non-fermented deer antler extract (NFA) and then subjected the mice to exercise in the form of swimming. The mice administered 500 mg/kg/day of FA showed a significant increase in swimming time compared with mice administered placebo (16.55 min vs. 21.64 min, P < 0.05). Serum lactate dehydrogenase (LDH), the marker of the liver and muscle damage, was significantly lower in FA groups. However, NFA groups did not show significantly different swimming time or serum LDH from that of the control group. Moreover, the FA-500 group had significantly higher hepatic superoxide dismutase (SOD) activity after forced swimming than the control and NFA groups (P < 0.05). These findings suggest that fermentation may increase the exercise endurance capacity of the deer antler.

Original languageEnglish
Pages (from-to)1716-1722
Number of pages7
JournalBioscience, Biotechnology and Biochemistry
Issue number10
Publication statusPublished - 2014

Bibliographical note

Publisher Copyright:
© 2014 Japan Society for Bioscience, Biotechnology, and Agrochemistry.


  • Deer antler
  • Endurance capacity
  • Fatigue
  • Fermentation
  • Forced swimming test

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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