TY - JOUR
T1 - Enhancement of mitochondrial function correlates with the extension of lifespan by caloric restriction and caloric restriction mimetics in yeast
AU - Choi, Kyung Mi
AU - Lee, Hye Lan
AU - Kwon, Young Yon
AU - Kang, Mi Sun
AU - Lee, Sung Keun
AU - Lee, Cheol Koo
N1 - Funding Information:
This work was supported by the National Research Foundation of Korea Grant funded by the Korean government (Grant No. 2006-2005313 and NRF-2011-0030137 ).
PY - 2013/11/8
Y1 - 2013/11/8
N2 - Caloric restriction mimetics (CRMs) have been developed to mimic the effects of caloric restriction (CR). However, research reports for the effects of CRMs are often times inconsistent across different research groups. Therefore, in this study, we compared seven identified CRMs which extend the lifespans of various organisms including caffeine, curcumin, dapsone, metformin, rapamycin, resveratrol, and spermidine to CR for mitochondrial function in a single model, Saccharomyces cerevisiae. In this organism, rapamycin extended chronological lifespan (CLS), but other CRMs failed to extend CLS. Rapamycin enhanced mitochondrial function like CR did, but other CRMs did not. Both CR and rapamycin worked on mitochondrial function, but they worked at different windows of time during the chronological aging process.
AB - Caloric restriction mimetics (CRMs) have been developed to mimic the effects of caloric restriction (CR). However, research reports for the effects of CRMs are often times inconsistent across different research groups. Therefore, in this study, we compared seven identified CRMs which extend the lifespans of various organisms including caffeine, curcumin, dapsone, metformin, rapamycin, resveratrol, and spermidine to CR for mitochondrial function in a single model, Saccharomyces cerevisiae. In this organism, rapamycin extended chronological lifespan (CLS), but other CRMs failed to extend CLS. Rapamycin enhanced mitochondrial function like CR did, but other CRMs did not. Both CR and rapamycin worked on mitochondrial function, but they worked at different windows of time during the chronological aging process.
KW - ATP
KW - Caloric restriction
KW - Caloric restriction mimetics
KW - Mitochondrial membrane potential
KW - Rapamycin
KW - Reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=84887428133&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2013.10.049
DO - 10.1016/j.bbrc.2013.10.049
M3 - Article
C2 - 24141116
AN - SCOPUS:84887428133
SN - 0006-291X
VL - 441
SP - 236
EP - 242
JO - Biochemical and biophysical research communications
JF - Biochemical and biophysical research communications
IS - 1
ER -