Enhancing microbial lipids yield for biodiesel production by oleaginous yeast Lipomyces starkeyi fermentation: A review

Le Zhang; Jonathan T.E. Lee; Yong Sik Ok; Yanjun Dai; Yen Wah Tong

doi:10.1016/j.biortech.2021.126294

Enhancing microbial lipids yield for biodiesel production by oleaginous yeast Lipomyces starkeyi fermentation: A review

Le Zhang, Jonathan T.E. Lee, Yong Sik Ok, Yanjun Dai, Yen Wah Tong

Research output: Contribution to journal › Review article › peer-review

17 Citations (Scopus)

Abstract

The enhanced production of microbial lipids suitable for manufacturing biodiesel from oleaginous yeast Lipomyces starkeyi is critically reviewed. Recent advances in several aspects involving the biosynthetic pathways of lipids, current conversion efficiencies using various carbon sources, intensification strategies for improving lipid yield and productivity in L. starkeyi fermentation, and lipid extraction approaches are analyzed from about 100 papers for the past decade. Key findings on strategies are summarized, including (1) optimization of parameters, (2) cascading two-stage systems, (3) metabolic engineering strategies, (4) mutagenesis followed by selection, and (5) co-cultivation of yeast and algae. The current technical limitations are analyzed. Research suggestions like examination of more gene targets via metabolic engineering are proposed. This is the first comprehensive review on the latest technical advances in strategies from the perspective of process and metabolic engineering to further increase the lipid yield and productivity from L. starkeyi fermentation.

Original language	English
Article number	126294
Journal	Bioresource technology
Volume	344
DOIs	https://doi.org/10.1016/j.biortech.2021.126294
Publication status	Published - 2022 Jan

Keywords

Bioprocess engineering
Intensification strategies
Lipid production
Metabolic engineering
Microbial biodiesel

ASJC Scopus subject areas

Bioengineering
Environmental Engineering
Renewable Energy, Sustainability and the Environment
Waste Management and Disposal

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biortech.2021.126294

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title = "Enhancing microbial lipids yield for biodiesel production by oleaginous yeast Lipomyces starkeyi fermentation: A review",

abstract = "The enhanced production of microbial lipids suitable for manufacturing biodiesel from oleaginous yeast Lipomyces starkeyi is critically reviewed. Recent advances in several aspects involving the biosynthetic pathways of lipids, current conversion efficiencies using various carbon sources, intensification strategies for improving lipid yield and productivity in L. starkeyi fermentation, and lipid extraction approaches are analyzed from about 100 papers for the past decade. Key findings on strategies are summarized, including (1) optimization of parameters, (2) cascading two-stage systems, (3) metabolic engineering strategies, (4) mutagenesis followed by selection, and (5) co-cultivation of yeast and algae. The current technical limitations are analyzed. Research suggestions like examination of more gene targets via metabolic engineering are proposed. This is the first comprehensive review on the latest technical advances in strategies from the perspective of process and metabolic engineering to further increase the lipid yield and productivity from L. starkeyi fermentation.",

keywords = "Bioprocess engineering, Intensification strategies, Lipid production, Metabolic engineering, Microbial biodiesel",

author = "Le Zhang and Lee, {Jonathan T.E.} and Ok, {Yong Sik} and Yanjun Dai and Tong, {Yen Wah}",

note = "Funding Information: This research is supported by the National Research Foundation , Prime Minister{\textquoteright}s Office, Singapore under its Campus for Research Excellence and Technological Enterprise (CREATE) Programme. Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2022",

month = jan,

doi = "10.1016/j.biortech.2021.126294",

language = "English",

volume = "344",

journal = "Bioresource Technology",

issn = "0960-8524",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Enhancing microbial lipids yield for biodiesel production by oleaginous yeast Lipomyces starkeyi fermentation

T2 - A review

AU - Zhang, Le

AU - Lee, Jonathan T.E.

AU - Ok, Yong Sik

AU - Dai, Yanjun

AU - Tong, Yen Wah

N1 - Funding Information: This research is supported by the National Research Foundation , Prime Minister’s Office, Singapore under its Campus for Research Excellence and Technological Enterprise (CREATE) Programme. Publisher Copyright: © 2021 Elsevier Ltd

PY - 2022/1

Y1 - 2022/1

N2 - The enhanced production of microbial lipids suitable for manufacturing biodiesel from oleaginous yeast Lipomyces starkeyi is critically reviewed. Recent advances in several aspects involving the biosynthetic pathways of lipids, current conversion efficiencies using various carbon sources, intensification strategies for improving lipid yield and productivity in L. starkeyi fermentation, and lipid extraction approaches are analyzed from about 100 papers for the past decade. Key findings on strategies are summarized, including (1) optimization of parameters, (2) cascading two-stage systems, (3) metabolic engineering strategies, (4) mutagenesis followed by selection, and (5) co-cultivation of yeast and algae. The current technical limitations are analyzed. Research suggestions like examination of more gene targets via metabolic engineering are proposed. This is the first comprehensive review on the latest technical advances in strategies from the perspective of process and metabolic engineering to further increase the lipid yield and productivity from L. starkeyi fermentation.

AB - The enhanced production of microbial lipids suitable for manufacturing biodiesel from oleaginous yeast Lipomyces starkeyi is critically reviewed. Recent advances in several aspects involving the biosynthetic pathways of lipids, current conversion efficiencies using various carbon sources, intensification strategies for improving lipid yield and productivity in L. starkeyi fermentation, and lipid extraction approaches are analyzed from about 100 papers for the past decade. Key findings on strategies are summarized, including (1) optimization of parameters, (2) cascading two-stage systems, (3) metabolic engineering strategies, (4) mutagenesis followed by selection, and (5) co-cultivation of yeast and algae. The current technical limitations are analyzed. Research suggestions like examination of more gene targets via metabolic engineering are proposed. This is the first comprehensive review on the latest technical advances in strategies from the perspective of process and metabolic engineering to further increase the lipid yield and productivity from L. starkeyi fermentation.

KW - Bioprocess engineering

KW - Intensification strategies

KW - Lipid production

KW - Metabolic engineering

KW - Microbial biodiesel

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U2 - 10.1016/j.biortech.2021.126294

DO - 10.1016/j.biortech.2021.126294

M3 - Review article

C2 - 34748983

AN - SCOPUS:85119250780

SN - 0960-8524

VL - 344

JO - Bioresource Technology

JF - Bioresource Technology

M1 - 126294

ER -

Enhancing microbial lipids yield for biodiesel production by oleaginous yeast Lipomyces starkeyi fermentation: A review

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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