Influenza A virus (IAV) infection is a global public health concern. It causes respiratory diseases ranging from mild illness to fatal disease. Natural killer (NK) cells are an innate immune component that kill infected cells and secrete cytokines to modulate the adaptive immune system; they constitute the first-line defense and play important roles in controlling IAV infection. This study evaluated the effect of daily administration of heat-treated Lactobacillus plantarum nF1-fortified yogurt on immunity and protection against IAV infection. Mice administered with heat-treated L. plantarum nF1-fortified yogurt showed elevated NK cell-related cytokine expression levels. Daily administration of the L. plantarum nF1-fortified yogurt before IAV infection also enhanced splenic NK activity, lung inflammatory cytokine responses, and survival rate. Thus, daily administration of nF1-fortified yogurt enhances host immunity and helps prevent IAV infection.
Bibliographical noteFunding Information:
This study was funded by Purmil Co. Ltd. (Seoul, Korea) and the School of Life Sciences & Biotechnology of Korea University for BK21PLUS. The authors thank the Korea University-CJ Food Safety Center (Seoul, Korea) for providing the equipment and facilities.
© 2018 American Dairy Science Association
- heat-treated Lactobacillus plantarum nF1
- natural killer cell activity
ASJC Scopus subject areas
- Food Science
- Animal Science and Zoology