ent-Kaurane diterpenoids from Isodon japonicus

Seong Su Hong, Seon A. Lee, Xiang Hua Han, Ji Sang Hwang, Chul Lee, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Heesoon Lee, Bang Yeon Hwang

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Five ent-kaurane diterpenoids, 6β,7β,14β-trihydroxy- 1α,19-diacetoxy-7α,20-epoxy-ent-kaur-16-en-15-one (1), 1α,6β,7β-trihydroxy-11α,19-diacetoxy-7α, 20-epoxy-ent-kaur-16-en-15-one (2), 6-hydroxy-1α,19-diacetoxy-6,7-seco- ent-kaur-16-en-15-one-7,20-olide (3), 19-hydroxy-1α,6-diacetoxy-6,7-seco- ent-kaur-16-en-15-one-7,20-olide (4), and 6-aldehyde1α,19-diacetoxy-6,7- seco-ent-kaur-16-en-15-one-7,20-olide (5), along with 10 known ent-kaurane diterpenoids, pseurata C (6), longikaurin C (7), effusanin C (8), longikaurin B (9), longikaurin D (10), effusanin D (11), excisanin B (12), lasiokaurin (13), megathyrin A (14), and loxothyrin A (15), were isolated from the aerial parts of Isodon japonicus. Their structures were determined on the basis of spectroscopic (1D-, 2D-NMR and MS) and chemical evidence. The isolates were evaluated for their inhibitory effects on LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells.

Original languageEnglish
Pages (from-to)1055-1058
Number of pages4
JournalJournal of Natural Products
Issue number6
Publication statusPublished - 2008 Jun

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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