Entosis: Cell-in-cell formation that kills through entotic cell death

O. Florey, S. E. Kim, M. Overholtzer

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Entosis is a cell-in-cell formation mechanism that targets viable cells for uptake in epithelial cell cultures and human tumors. Entotic cells control their own engulfment, by invading into their hosts in a Rho-GTPase and actomyosin-dependent manner. Although entotic cells are internalized while alive, most eventually undergo a non-apoptotic form of cell death, called entotic cell death, that is executed non-cell-autonomously by autophagy proteins and lysosomes. Here we review the current understanding of entosis and entotic cell death and discuss the potential roles of this process in cancer.

Original languageEnglish
Pages (from-to)861-866
Number of pages6
JournalCurrent Molecular Medicine
Issue number9
Publication statusPublished - 2015 Nov 1
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 Bentham Science Publishers.


  • Autophagy
  • Cannibalism
  • Cell competition
  • Cell-in-cell
  • Engulfment
  • Entosis
  • Entotic cell death
  • LAP
  • Phagocytosis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology


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