Enzymatic 'charging' of synthetic polymers

Jingyi Rao; Anzar Khan

doi:10.1039/c4py01527d

Enzymatic 'charging' of synthetic polymers

Jingyi Rao, Anzar Khan

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Actuated by an enzyme, a purely synthetic and chemically neutral polymer chain transforms into a chemically charged cationic structure. This biologically triggered structural change enables the polymer chain to recognize a negatively charged biomolecule (RNA) through electrostatic interactions in aqueous environment. The supramolecular recognition event ultimately leads to the assembly of oppositely charged, artificial and natural polymer chains, into the polyion complex-based nanoparticles.

Original language	English
Pages (from-to)	686-690
Number of pages	5
Journal	Polymer Chemistry
Volume	6
Issue number	5
DOIs	https://doi.org/10.1039/c4py01527d
Publication status	Published - 2015 Feb 7

ASJC Scopus subject areas

Bioengineering
Biochemistry
Polymers and Plastics
Organic Chemistry

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abstract = "Actuated by an enzyme, a purely synthetic and chemically neutral polymer chain transforms into a chemically charged cationic structure. This biologically triggered structural change enables the polymer chain to recognize a negatively charged biomolecule (RNA) through electrostatic interactions in aqueous environment. The supramolecular recognition event ultimately leads to the assembly of oppositely charged, artificial and natural polymer chains, into the polyion complex-based nanoparticles.",

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Enzymatic 'charging' of synthetic polymers

Abstract

ASJC Scopus subject areas

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