Enzymatic transformation of ginsenosides in korean red ginseng (Panax ginseng meyer) extract prepared by spezyme and optidex

Hyeon Son Choi, Sun Young Kim, Yooheon Park, Eun Young Jung, Hyung Joo Suh

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Background: In this study, we examined the effects of various enzymes on chemical conversions of ginsenosides in ginseng extract prepared by amylases. Methods: Rapidase, Econase CE, Viscozyme, Ultraflo L, and Cytolase PCL5 were used for secondary enzymatic hydrolysis after amylase treatment of ginseng extract, and ginsenoside contents, skin permeability, and chemical compositions including total sugar, acidic polysaccharide, and polyphenols were determined on the hydrolyzed ginseng extract. Results: Rapidase treatment significantly elevated total ginsenoside contents compared with the control (p < 0.05). In particular, deglycosylated ginsenosides including Rg3, which are known as bioactive compounds, were significantly increased after Rapidase treatment (p < 0.05). The Rapidase-treated group also increased the skin permeability of polyphenols compared with the control, showing the highest level of total sugar content among the enzyme treatment groups. Conclusion: This result showed that Rapidase induced the conversion of ginsenoside glycosides to aglycones. Meanwhile, Cytolase PCL5 and Econase treatments led to a significant increase of uronic acid (acidic polysaccharide) level. Taken together, our data showed that the treatments of enzymes including Rapidase are useful for the conversion and increase of ginsenosides in ginseng extracts or products.

Original languageEnglish
Pages (from-to)264-269
Number of pages6
JournalJournal of Ginseng Research
Issue number4
Publication statusPublished - 2014 Oct 15

Bibliographical note

Publisher Copyright:
© 2014, The Korean Society of Ginseng, Published by Elsevier. All rights reserved.


  • Enzymatic transformation
  • Ginsenosides
  • Korean Red Ginseng extracts
  • Panax ginseng Meyer

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Complementary and alternative medicine


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