Eosinophilic Chronic Rhinosinusitis and Pathogenic Role of Protease

Jaehyeong Kim, Sooun Kwak, Juhyun Lee, Il Ho Park, Seung Hoon Lee, Jae Min Shin, Tae Hoon Kim

Research output: Contribution to journalReview articlepeer-review


Chronic rhinosinusitis (CRS) is an inflammation of the nasal and paranasal sinus mucosa, and eosinophilic CRS (eCRS) is a subtype characterized by significant eosinophil infiltration and immune response by T-helper-2 cells. The pathogenesis of eCRS is heterogeneous and involves various environmental and host factors. Proteases from external sources, such as mites, fungi, and bacteria, have been implicated in inducing type 2 inflammatory reactions. The balance between these proteases and endogenous protease inhibitors (EPIs) is considered important, and their imbalance can potentially lead to type 2 inflammatory reactions, such as eCRS. In this review, we discuss various mechanisms by which exogenous proteases influence eCRS and highlight the emerging role of endogenous protease inhibitors in eCRS pathogenesis.

Original languageEnglish
Article number17372
JournalInternational journal of molecular sciences
Issue number24
Publication statusPublished - 2023 Dec

Bibliographical note

Publisher Copyright:
© 2023 by the authors.


  • chronic rhinosinusitis
  • endogenous protease inhibitor
  • eosinophilic chronic rhinosinusitis
  • protease

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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