Cefazolin is a strong epileptogenic agent. We describe two patients presenting with status epilepticus, apparently caused by intrathecal leakage of cefazolin via incidental dural puncture during spinal epidural adhesiolysis. Our cases suggest that the local use of antibiotics, particularly cefazolin, in the form of a mixture with contrast medium during a spinal procedure is not advisable, because of the possible incidental intrathecal leakage and the high convulsive potential of the antibiotics.
Bibliographical noteFunding Information:
This study was supported by grants from Korea University (K0814321).
- Adverse effects
- Intrathecal injection
- Status epilepticus
ASJC Scopus subject areas
- Clinical Neurology