Epidural adhesiolysis complicated by cefazolin-induced status epilepticus: Two cases

Jeong Yoon Choi; Hung Youl Seok; Sang Heon Lee; Byung Jo Kim; Kun Woo Park; Ki Young Jung

doi:10.1016/j.clineuro.2008.06.007

Epidural adhesiolysis complicated by cefazolin-induced status epilepticus: Two cases

Jeong Yoon Choi, Hung Youl Seok, Sang Heon Lee, Byung Jo Kim, Kun Woo Park, Ki Young Jung

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Cefazolin is a strong epileptogenic agent. We describe two patients presenting with status epilepticus, apparently caused by intrathecal leakage of cefazolin via incidental dural puncture during spinal epidural adhesiolysis. Our cases suggest that the local use of antibiotics, particularly cefazolin, in the form of a mixture with contrast medium during a spinal procedure is not advisable, because of the possible incidental intrathecal leakage and the high convulsive potential of the antibiotics.

Original language	English
Pages (from-to)	1041-1043
Number of pages	3
Journal	Clinical Neurology and Neurosurgery
Volume	110
Issue number	10
DOIs	https://doi.org/10.1016/j.clineuro.2008.06.007
Publication status	Published - 2008 Dec

Bibliographical note

Funding Information:
This study was supported by grants from Korea University (K0814321).

Keywords

Adverse effects
Cefazolin
Intrathecal injection
Status epilepticus

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1016/j.clineuro.2008.06.007

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title = "Epidural adhesiolysis complicated by cefazolin-induced status epilepticus: Two cases",

abstract = "Cefazolin is a strong epileptogenic agent. We describe two patients presenting with status epilepticus, apparently caused by intrathecal leakage of cefazolin via incidental dural puncture during spinal epidural adhesiolysis. Our cases suggest that the local use of antibiotics, particularly cefazolin, in the form of a mixture with contrast medium during a spinal procedure is not advisable, because of the possible incidental intrathecal leakage and the high convulsive potential of the antibiotics.",

keywords = "Adverse effects, Cefazolin, Intrathecal injection, Status epilepticus",

author = "Choi, {Jeong Yoon} and Seok, {Hung Youl} and Lee, {Sang Heon} and Kim, {Byung Jo} and Park, {Kun Woo} and Jung, {Ki Young}",

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T2 - Two cases

AU - Choi, Jeong Yoon

AU - Seok, Hung Youl

AU - Lee, Sang Heon

AU - Kim, Byung Jo

AU - Park, Kun Woo

AU - Jung, Ki Young

N1 - Funding Information: This study was supported by grants from Korea University (K0814321).

PY - 2008/12

Y1 - 2008/12

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AB - Cefazolin is a strong epileptogenic agent. We describe two patients presenting with status epilepticus, apparently caused by intrathecal leakage of cefazolin via incidental dural puncture during spinal epidural adhesiolysis. Our cases suggest that the local use of antibiotics, particularly cefazolin, in the form of a mixture with contrast medium during a spinal procedure is not advisable, because of the possible incidental intrathecal leakage and the high convulsive potential of the antibiotics.

KW - Adverse effects

KW - Cefazolin

KW - Intrathecal injection

KW - Status epilepticus

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IS - 10

ER -

Epidural adhesiolysis complicated by cefazolin-induced status epilepticus: Two cases

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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