Epidural adhesiolysis complicated by cefazolin-induced status epilepticus: Two cases

Jeong Yoon Choi, Hung Youl Seok, Sang Heon Lee, Byung Jo Kim, Kun Woo Park, Ki Young Jung

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)


    Cefazolin is a strong epileptogenic agent. We describe two patients presenting with status epilepticus, apparently caused by intrathecal leakage of cefazolin via incidental dural puncture during spinal epidural adhesiolysis. Our cases suggest that the local use of antibiotics, particularly cefazolin, in the form of a mixture with contrast medium during a spinal procedure is not advisable, because of the possible incidental intrathecal leakage and the high convulsive potential of the antibiotics.

    Original languageEnglish
    Pages (from-to)1041-1043
    Number of pages3
    JournalClinical Neurology and Neurosurgery
    Issue number10
    Publication statusPublished - 2008 Dec

    Bibliographical note

    Funding Information:
    This study was supported by grants from Korea University (K0814321).


    • Adverse effects
    • Cefazolin
    • Intrathecal injection
    • Status epilepticus

    ASJC Scopus subject areas

    • Surgery
    • Clinical Neurology


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