Epigenetic regulation of autophagy by histone-modifying enzymes under nutrient stress

Young Suk Yu, Hyunkyung Kim, Keun Il Kim, Sung Hee Baek

    Research output: Contribution to journalReview articlepeer-review

    10 Citations (Scopus)

    Abstract

    Autophagy is an evolutionarily conserved catabolic process that is induced in response to various stress factors in order to protect cells and maintain cellular homeostasis by degrading redundant components and dysfunctional organelles. Dysregulation of autophagy has been implicated in several conditions such as cancer, neurodegenerative diseases, and metabolic disorders. Although autophagy has been commonly considered as a cytoplasmic process, accumulating evidence has revealed that epigenetic regulation within the nucleus is also important for regulation of autophagy. In particular, when energy homeostasis is disrupted, for instance due to nutrient deprivation, cells increase autophagic activity at the transcriptional level, thereby also increasing the extent of overall autophagic flux. The transcription of genes associated with autophagy is strictly regulated by epigenetic factors through a network of histone-modifying enzymes along with histone modifications. A better understanding of the complex regulatory mechanisms of autophagy could reveal potential new therapeutic targets for autophagy-related diseases. In this review, we discuss the epigenetic regulation of autophagy in response to nutrient stress, focusing on histone-modifying enzymes and histone modifications.

    Original languageEnglish
    Pages (from-to)1430-1436
    Number of pages7
    JournalCell Death and Differentiation
    Volume30
    Issue number6
    DOIs
    Publication statusPublished - 2023 Jun

    Bibliographical note

    Publisher Copyright:
    © 2023, The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare.

    ASJC Scopus subject areas

    • Molecular Biology
    • Cell Biology

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