Escitalopram efficacy in depression: A cross-ethnicity examination of the serotonin transporter promoter polymorphism

Chad A. Bousman; Jerome Sarris; Eun Soo Won; Hun Soo Chang; Ajeet Singh; Hwa Young Lee; Byung Joo Ham; Chay Hoon Tan; Min Soo Lee; Chee H. Ng

doi:10.1097/JCP.0000000000000165

Escitalopram efficacy in depression: A cross-ethnicity examination of the serotonin transporter promoter polymorphism

Chad A. Bousman, Jerome Sarris, Eun Soo Won, Hun Soo Chang, Ajeet Singh, Hwa Young Lee, Byung Joo Ham, Chay Hoon Tan, Min Soo Lee, Chee H. Ng

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Current evidence suggests that polymorphism in the serotonin transporter gene (5-HTTLPR) predicts antidepressant efficacy in whites but less so in Asians. However, it is not clear whether this effect can be observed for specific types of antidepressant drugs. White (n = 47) and Korean (n = 118) participants with major depressive disorder were treated with escitalopram and assessed over 8 weeks. Among those with the l/l but not l/s or s/s genotypes, whites had greater depression score reductions, response rates, and remission rates compared with Koreans. Our results suggest that 5-HTTLPR predicts escitalopram efficacy in an ethnicity-dependent manner.

Original language	English
Pages (from-to)	645-648
Number of pages	4
Journal	Journal of Clinical Psychopharmacology
Volume	34
Issue number	5
DOIs	https://doi.org/10.1097/JCP.0000000000000165
Publication status	Published - 2014 Oct
Externally published	Yes

Keywords

antidepressant
efficacy
genotype
pharmacogenetic

ASJC Scopus subject areas

Psychiatry and Mental health
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/JCP.0000000000000165

Cite this

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title = "Escitalopram efficacy in depression: A cross-ethnicity examination of the serotonin transporter promoter polymorphism",

abstract = "Current evidence suggests that polymorphism in the serotonin transporter gene (5-HTTLPR) predicts antidepressant efficacy in whites but less so in Asians. However, it is not clear whether this effect can be observed for specific types of antidepressant drugs. White (n = 47) and Korean (n = 118) participants with major depressive disorder were treated with escitalopram and assessed over 8 weeks. Among those with the l/l but not l/s or s/s genotypes, whites had greater depression score reductions, response rates, and remission rates compared with Koreans. Our results suggest that 5-HTTLPR predicts escitalopram efficacy in an ethnicity-dependent manner.",

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T2 - A cross-ethnicity examination of the serotonin transporter promoter polymorphism

AU - Bousman, Chad A.

AU - Sarris, Jerome

AU - Won, Eun Soo

AU - Chang, Hun Soo

AU - Singh, Ajeet

AU - Lee, Hwa Young

AU - Ham, Byung Joo

AU - Tan, Chay Hoon

AU - Lee, Min Soo

AU - Ng, Chee H.

PY - 2014/10

Y1 - 2014/10

N2 - Current evidence suggests that polymorphism in the serotonin transporter gene (5-HTTLPR) predicts antidepressant efficacy in whites but less so in Asians. However, it is not clear whether this effect can be observed for specific types of antidepressant drugs. White (n = 47) and Korean (n = 118) participants with major depressive disorder were treated with escitalopram and assessed over 8 weeks. Among those with the l/l but not l/s or s/s genotypes, whites had greater depression score reductions, response rates, and remission rates compared with Koreans. Our results suggest that 5-HTTLPR predicts escitalopram efficacy in an ethnicity-dependent manner.

AB - Current evidence suggests that polymorphism in the serotonin transporter gene (5-HTTLPR) predicts antidepressant efficacy in whites but less so in Asians. However, it is not clear whether this effect can be observed for specific types of antidepressant drugs. White (n = 47) and Korean (n = 118) participants with major depressive disorder were treated with escitalopram and assessed over 8 weeks. Among those with the l/l but not l/s or s/s genotypes, whites had greater depression score reductions, response rates, and remission rates compared with Koreans. Our results suggest that 5-HTTLPR predicts escitalopram efficacy in an ethnicity-dependent manner.

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KW - efficacy

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KW - pharmacogenetic

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Escitalopram efficacy in depression: A cross-ethnicity examination of the serotonin transporter promoter polymorphism

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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