Esophageal dysmotility and acid sensitivity in patients with mitral valve prolapse and chest pain

R. J H Hammett, R. D. Hansen, M. Lorang, Young-Tae Bak, J. E. Kellow

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Mitral valve prolapse (MVP) patients often experience non-cardiac chest pain. The aims of this study were to determine, in patients with non-cardiac chest pain: (i) whether esophageal dysmotility is more common in patients with MVP than in patients without MVP; and (ii) if acid sensitivity is an important cause of the chest pain in MVP patients. Esophageal manometry and acid perfusion testing were performed in 277 consecutive patients with non-cardiac chest pain. Patients with MVP (13 female, one male; mean age 49 years) were more likely (P = 0.01) to have esophageal dysmotility, while acid perfusion was less likely (P < 0.05) to provoke their chest pain, than in patients without MVP. The most common esophageal motor abnormalities detected in patients with and without MVP were diffuse esophageal spasm (prevalence, 57%) and non-specific motor disorder (prevalence, 9%), respectively. This study, the first large prospective series examining possible esophageal sensorimotor correlates of chest pain in MVP patients, demonstrates that in the absence of a cardiac cause for chest pain, a specific esophageal motility disorder should be excluded, rather than assuming the chest pain is likely to be due to acid sensitivity.

Original languageEnglish
Pages (from-to)73-76
Number of pages4
JournalDiseases of the Esophagus
Issue number2
Publication statusPublished - 2003 Aug 26
Externally publishedYes


  • Acid perfusion testing
  • Diffuse esophageal spasm
  • Esophageal manometry
  • Mitral valve prolapse
  • Non-cardiac chest pain

ASJC Scopus subject areas

  • Gastroenterology


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