Abstract
Though hyaluronic acid (HA)-based hydrogel has drawn great attention in biomedical society, it's long molecular weights sometimes have been problematic due to its difficulty in handling. After reduction of its high molecular weight into smaller sizes with various concentrations of hydrogen chloride solutions, its chemical and biological properties have been examined by changes in viscosity, FTIR spectroscopy and gel permeation chromatography as well as cellular interactions. While FTIR analysis indicated maintenance of its original chemical structures, its viscosity has been remarkably reduced and its extent was dependent upon the employment of acid concentrations. After controlling its molecular weight to approximately 100 kDa and coupling of aminopropymethacrylate to the treated HA, we evaluated in vitro cellular interactions and cell proliferations of the HA-poly(ethylene oxide) (PEO) hydrogel.
| Original language | English |
|---|---|
| Pages (from-to) | 745-748 |
| Number of pages | 4 |
| Journal | Key Engineering Materials |
| Volume | 342-343 |
| DOIs | |
| Publication status | Published - 2007 |
Bibliographical note
Funding Information:The authors express their gratitude to Dr. Scott Stauffer of University of Dayton Research Institute for stimulating scientific discussions and technical assistance. The authors would like to thank Richard Zehring of Innovative Scientific Solutions, Inc. for his excellent assistance with the combustion facility. This work was funded by the Air Force Research Laboratory contract nos. FA8650-12-C-2236 and FA8650-15-D-2518 and by the Air Force Office of Scientific Research (14RQ06COR) (Dr. Chiping Li, Program Officer). This work was cleared for public release (88ABW-2015-4424).
Keywords
- Evaluation
- Hyaluronic acid
- In situ hydrogel
- Molecular weight
- Poly(ethylene oxide)
ASJC Scopus subject areas
- General Materials Science
- Mechanics of Materials
- Mechanical Engineering