Evaluation of chemical interactions between small molecules in the gas phase using chemical force microscopy

Jieun Lee, Soomi Ju, In Tae Kim, Sun Hwa Jung, Sun Joon Min, Chulki Kim, Sang Jun Sim, Sang Kyung Kim

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Chemical force microscopy analyzes the interactions between various chemical/biochemical moieties in situ. In this work we examined force-distance curves and lateral force to measure the interaction between modified AFM tips and differently functionalized molecular monolayers. Especially for the measurements in gas phase, we investigated the effect of humidity on the analysis of force-distance curves and the images in lateral force mode. Flat chemical patterns composed of different functional groups were made through micro-contact printing and lateral force mode provided more resolved analysis of the chemical patterns. From the images of 1-octadecanethiol/11-mercapto-1-undecanoic acid patterns, the amine group functionalized tip brought out higher contrast of the patterns than an intact silicon nitride tip owing to the additional chemical interaction between carboxyl and amine groups. For more complex chemical interactions, relative chemical affinities toward specific peptides were assessed on the pattern of 1-octadecanethiol/phenyl-terminated alkanethiol. The lateral image of chemical force microscopy reflected specific preference of a peptide to phenyl group as well as the hydrophobic interaction.

Original languageEnglish
Pages (from-to)30683-30692
Number of pages10
JournalSensors (Switzerland)
Issue number12
Publication statusPublished - 2015 Dec 4

Bibliographical note

Publisher Copyright:
© 2015 by the authors; licensee MDPI, Basel, Switzerland.


  • Benzene specific peptide
  • Chemical force microscopy
  • Lateral force image
  • Micro-contact printing

ASJC Scopus subject areas

  • Analytical Chemistry
  • Information Systems
  • Instrumentation
  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering
  • Biochemistry


Dive into the research topics of 'Evaluation of chemical interactions between small molecules in the gas phase using chemical force microscopy'. Together they form a unique fingerprint.

Cite this