Evaluation of safety and efficacy of adipose-derived stem cells in rat myocardial infarction model using hexadecyl-4-[124I]iodobenzoate for cell tracking

Min Hwan Kim, Kyo Chul Lee, Gwang Il An, Sang Keun Woo, Noh Won Park, Byung Il Kim, Ki Dong Eom, Kwang Il Kim, Tae Sup Lee, Chan Wha Kim, Jeongsoo Yoo, Joo Hyun Kang, Yong Jin Lee

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

This study was aimed to evaluate the effect of 124I-labeling with hexadecyl-4-iodobenzoate (HIB) on gene expression related to cell cycle, DNA repair, transcription, proliferation and differentiation of adipose-derived stem cells (ADSCs). [124I]HIB showed high labeling efficiency with ADSCs (51.3±1.3%, 0.3-2.0Bq/cell) and there is no morphological change of ADSCs. In the microarray analysis of gene expression pattern, differences were not observed between non-labeled and [124I]HIB-labeled ADSCs. We demonstrated that 124I-labeling with HIB did not affect the biological properties of ADSCs.

Original languageEnglish
Pages (from-to)116-123
Number of pages8
JournalApplied Radiation and Isotopes
Volume108
DOIs
Publication statusPublished - 2016 Feb 1

Bibliographical note

Funding Information:
This study was supported by the Nuclear R&D (Grant code: NRF-2012M2A2A7013480 and 2011-0030162 ) and Basic Science Research (grant code: NRF-2012R1A1A2044945 , NRF-2011-0012830 ) Programs of NRF, funded by MEST-Republic of Korea .

Publisher Copyright:
© 2015 Elsevier Ltd.

Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.

Keywords

  • Adipose-derived stem cells
  • Direct labeling agent
  • Hexadecyl-4-[I]iodobenzoate
  • Microarray
  • Myocardial infarction

ASJC Scopus subject areas

  • Radiation

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