Evaluation of silica nanoparticle toxicity after topical exposure for 90 days

Hwa Jung Ryu, Nak Won Seong, Byoung Joon So, Heung Sik Seo, Jun Ho Kim, Jeong Sup Hong, Myeong Kyu Park, Min Seok Kim, Yu Ri Kim, Kyu Bong Cho, Mu Yeb Seo, Meyoung-Kon Kim, Eun Ho Maeng, Sang Wook Son

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)


Silica is a very common material that can be found in both crystalline and amorphous forms. Well-known toxicities of the lung can occur after exposure to the crystalline form of silica. However, the toxicities of the amorphous form of silica have not been thoroughly studied. The majority of in vivo studies of amorphous silica nanoparticles (NPs) were performed using an inhalation exposure method. Since silica NPs can be commonly administered through the skin, a study of dermal silica toxicity was necessary to determine any harmful effects from dermal exposures. The present study focused on the results of systemic toxicity after applying 20 nm colloidal silica NPs on rat skin for 90 days, in accordance with the Organization for Economic Cooperation and Development test guideline 411 with a good laboratory practice system. Unlike the inhalation route or gastrointestinal route, the contact of silica NPs through skin did not result in any toxicity or any change in internal organs up to a dose of 2,000 mg/kg in rats.

Original languageEnglish
Pages (from-to)127-136
Number of pages10
JournalInternational Journal of Nanomedicine
Publication statusPublished - 2014 Dec 15

Bibliographical note

Publisher Copyright:
© 2014 Ryu et al.


  • Dermal route
  • Silica nanoparticles
  • Toxicity

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry


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