Evaluation of the cytotoxicity of gold nanoparticle-quercetin complex and its potential as a drug delivery vesicle

Pyo June Pak, Eun Byeol Go, Min Hee Hwang, Dong Gun Lee, Mi Ju Cho, Yong Hoon Joo, Namhyun Chung

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Recently, conjugates of medicinal herb-derived bioflavonoids, such as quercetin, and gold nanoparticles (GNPs) have gained attention as targeted drug delivery systems. In the present study, because quercetin is an important flavonoid with anticancer, anti-inflammatory, and anti-oxidant properties, GNP-quercetin complexes (GNPQs) were synthesized to investigate possible adverse effects such as cytotoxicity. We found that while quercetin was cytotoxic, GNPQs were not cytotoxic towards the RAW 264.7 and THP-1 cell lines. Therefore, GNPQs may serve as a potential drug delivery system for cancer treatment.

Original languageEnglish
Pages (from-to)145-147
Number of pages3
JournalJournal of Applied Biological Chemistry
Volume59
Issue number2
DOIs
Publication statusPublished - 2016 Jun

Bibliographical note

Funding Information:
This work was supported by a grant from National Research Foundation of Korea. (Grant No. NRF-2015R1A2A2A0100650).

Publisher Copyright:
© The Korean Society for Applied Biological Chemistry 2016.

Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.

Keywords

  • Citrate synthesis
  • Drug delivery system
  • Gold nanoparticle
  • Quercetin

ASJC Scopus subject areas

  • Bioengineering
  • Organic Chemistry

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