Evaluation of the cytotoxicity of gold nanoparticle-quercetin complex and its potential as a drug delivery vesicle

Pyo June Pak; Eun Byeol Go; Min Hee Hwang; Dong Gun Lee; Mi Ju Cho; Yong Hoon Joo; Namhyun Chung

doi:10.3839/jabc.2016.026

Evaluation of the cytotoxicity of gold nanoparticle-quercetin complex and its potential as a drug delivery vesicle

Pyo June Pak, Eun Byeol Go, Min Hee Hwang, Dong Gun Lee, Mi Ju Cho, Yong Hoon Joo, Namhyun Chung

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Recently, conjugates of medicinal herb-derived bioflavonoids, such as quercetin, and gold nanoparticles (GNPs) have gained attention as targeted drug delivery systems. In the present study, because quercetin is an important flavonoid with anticancer, anti-inflammatory, and anti-oxidant properties, GNP-quercetin complexes (GNPQs) were synthesized to investigate possible adverse effects such as cytotoxicity. We found that while quercetin was cytotoxic, GNPQs were not cytotoxic towards the RAW 264.7 and THP-1 cell lines. Therefore, GNPQs may serve as a potential drug delivery system for cancer treatment.

Original language	English
Pages (from-to)	145-147
Number of pages	3
Journal	Journal of Applied Biological Chemistry
Volume	59
Issue number	2
DOIs	https://doi.org/10.3839/jabc.2016.026
Publication status	Published - 2016 Jun

Keywords

Citrate synthesis
Drug delivery system
Gold nanoparticle
Quercetin

ASJC Scopus subject areas

Bioengineering
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3839/jabc.2016.026

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title = "Evaluation of the cytotoxicity of gold nanoparticle-quercetin complex and its potential as a drug delivery vesicle",

abstract = "Recently, conjugates of medicinal herb-derived bioflavonoids, such as quercetin, and gold nanoparticles (GNPs) have gained attention as targeted drug delivery systems. In the present study, because quercetin is an important flavonoid with anticancer, anti-inflammatory, and anti-oxidant properties, GNP-quercetin complexes (GNPQs) were synthesized to investigate possible adverse effects such as cytotoxicity. We found that while quercetin was cytotoxic, GNPQs were not cytotoxic towards the RAW 264.7 and THP-1 cell lines. Therefore, GNPQs may serve as a potential drug delivery system for cancer treatment.",

keywords = "Citrate synthesis, Drug delivery system, Gold nanoparticle, Quercetin",

author = "Pak, {Pyo June} and Go, {Eun Byeol} and Hwang, {Min Hee} and Lee, {Dong Gun} and Cho, {Mi Ju} and Joo, {Yong Hoon} and Namhyun Chung",

note = "Funding Information: This work was supported by a grant from National Research Foundation of Korea. (Grant No. NRF-2015R1A2A2A0100650). Publisher Copyright: {\textcopyright} The Korean Society for Applied Biological Chemistry 2016. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.",

year = "2016",

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doi = "10.3839/jabc.2016.026",

language = "English",

volume = "59",

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AU - Pak, Pyo June

AU - Go, Eun Byeol

AU - Hwang, Min Hee

AU - Lee, Dong Gun

AU - Cho, Mi Ju

AU - Joo, Yong Hoon

AU - Chung, Namhyun

N1 - Funding Information: This work was supported by a grant from National Research Foundation of Korea. (Grant No. NRF-2015R1A2A2A0100650). Publisher Copyright: © The Korean Society for Applied Biological Chemistry 2016. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.

PY - 2016/6

Y1 - 2016/6

N2 - Recently, conjugates of medicinal herb-derived bioflavonoids, such as quercetin, and gold nanoparticles (GNPs) have gained attention as targeted drug delivery systems. In the present study, because quercetin is an important flavonoid with anticancer, anti-inflammatory, and anti-oxidant properties, GNP-quercetin complexes (GNPQs) were synthesized to investigate possible adverse effects such as cytotoxicity. We found that while quercetin was cytotoxic, GNPQs were not cytotoxic towards the RAW 264.7 and THP-1 cell lines. Therefore, GNPQs may serve as a potential drug delivery system for cancer treatment.

AB - Recently, conjugates of medicinal herb-derived bioflavonoids, such as quercetin, and gold nanoparticles (GNPs) have gained attention as targeted drug delivery systems. In the present study, because quercetin is an important flavonoid with anticancer, anti-inflammatory, and anti-oxidant properties, GNP-quercetin complexes (GNPQs) were synthesized to investigate possible adverse effects such as cytotoxicity. We found that while quercetin was cytotoxic, GNPQs were not cytotoxic towards the RAW 264.7 and THP-1 cell lines. Therefore, GNPQs may serve as a potential drug delivery system for cancer treatment.

KW - Citrate synthesis

KW - Drug delivery system

KW - Gold nanoparticle

KW - Quercetin

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ER -

Evaluation of the cytotoxicity of gold nanoparticle-quercetin complex and its potential as a drug delivery vesicle

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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