Evaluation of waning immunity at 6 months after both trivalent and quadrivalent influenza vaccination in Korean children aged 6-35 months

Jee Hyun Lee, Hye Kyung Cho, Ki Hwan Kim, Jina Lee, Yae Jean Kim, Byung Wook Eun, Nam Hee Kim, Dong Ho Kim, Dae Sun Jo, Hwang Min Kim, Yun Kyung Kim

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    3 Citations (Scopus)


    Background: The titer of influenza vaccine-induced antibodies declines over time, and younger children have lower immunogenicity and shorter duration of immunity. This study aimed to compare persistence of antibody at 6 months after influenza vaccination according to influenza virus strains, vaccine type, antigen dose, and primed status in children aged 6 to 35 months. Methods: A total 124 healthy children aged 6 to 35 months were enrolled from September to December 2016 at 10 hospitals in Korea and randomly assigned to either a full dose of quadrivalent influenza vaccine or a half dose of trivalent influenza vaccine with Victoria B strain group. Hemagglutination inhibition antibody titers (that measure the seroprotection rates) were assessed for the recommended influenza strains at 6 months post vaccination. Results: The seroprotection rates at 6 months for strains A (H1N1), A (H3N2), B/Yamagata, and B/Victoria were 88.7%, 97.4%, 36.6%, and 27.6%, respectively. The seroprotection rates for A (H1N1), A (H3N2) and B (Victoria) were 91.4%, 98.7% and 27.5% in a full dose of quadrivalent vaccine vs. 83.7%, 94.6% and 27.9% in a half dose trivalent vaccine, respectively. The seroprotection rate for the B (Yamagata) strain was 23.8% in the quadrivalent group and 14.0% in the trivalent group. Conclusion: Persistence of antibodies at 6 months was more favorable against the influenza A strains than against the B strains. Persistence of antibodies to additional B strain at 6 months was superior in the quadrivalent vaccine group. The immunity of primed children with different B strains was not superior to that of the unprimed group with another B strain.

    Original languageEnglish
    Article numbere279
    JournalJournal of Korean medical science
    Issue number46
    Publication statusPublished - 2019 Dec 1

    Bibliographical note

    Funding Information:
    This work was supported by the SK Bioscience Corporation, Seongnam, Republic of Korea (l1700851).

    Publisher Copyright:
    © 2019 The Korean Academy of Medical Sciences.


    • Children
    • Hemagglutination
    • Immunity
    • Quadrivalent Influenza Vaccine
    • Trivalent Influenza Vaccine

    ASJC Scopus subject areas

    • General Medicine


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