TY - JOUR
T1 - Experimental and Theoretical Structural Characterization of Cu-Au Tripods for Photothermal Anticancer Therapy
AU - Nanda, Sitansu Sekhar
AU - Hembram, K. P.S.S.
AU - Lee, Jae Kap
AU - Kim, Kwangmeyung
AU - Selvan, Subramanian Tamil
AU - Yi, Dong Kee
N1 - Funding Information:
This work was supported by the Korean National Research Foundation (NRF-2018R1A2B6007786). The Server Farm Supercomputing Facility at Korea Institute of Science and Technology is also acknowledged.
Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/6/28
Y1 - 2019/6/28
N2 - Anisotropic metal nanostructures (e.g., Au-Ag, Au-Cu) are emerging for biomedical and catalytic applications in recent years. Herein, we report a modified synthesis of Cu-Au tripod nanocrystals through the controlled nucleation and growth process with judicious purification for photothermal based anticancer therapy. The distribution of nanocrystals in tripod was analyzed by STEM-EDX mapping, indicating the formation of Cu-Au alloy nanocrystals. Theoretical calculations showed the possible formation of alloy structures, that is, Cu3Au, Cu-Au, and CuAu3 and confirmed that their stability in the following order: CuAu3 < Cu-Au < Cu3Au. These stable tripods exhibited a well pronounced photothermal effect as demonstrated by experimental and simulation photothermal studies. Cancer cells treated with nanocrystals upon NIR laser exposure showed promising therapeutic effects.
AB - Anisotropic metal nanostructures (e.g., Au-Ag, Au-Cu) are emerging for biomedical and catalytic applications in recent years. Herein, we report a modified synthesis of Cu-Au tripod nanocrystals through the controlled nucleation and growth process with judicious purification for photothermal based anticancer therapy. The distribution of nanocrystals in tripod was analyzed by STEM-EDX mapping, indicating the formation of Cu-Au alloy nanocrystals. Theoretical calculations showed the possible formation of alloy structures, that is, Cu3Au, Cu-Au, and CuAu3 and confirmed that their stability in the following order: CuAu3 < Cu-Au < Cu3Au. These stable tripods exhibited a well pronounced photothermal effect as demonstrated by experimental and simulation photothermal studies. Cancer cells treated with nanocrystals upon NIR laser exposure showed promising therapeutic effects.
KW - Cu-Au tripods
KW - NIR laser
KW - bimetallic nanocrystals
KW - cancer cells
KW - photothermal therapy
UR - http://www.scopus.com/inward/record.url?scp=85068603834&partnerID=8YFLogxK
U2 - 10.1021/acsanm.9b00634
DO - 10.1021/acsanm.9b00634
M3 - Article
AN - SCOPUS:85068603834
SN - 2574-0970
VL - 2
SP - 3735
EP - 3742
JO - ACS Applied Nano Materials
JF - ACS Applied Nano Materials
IS - 6
ER -
