Abstract
Neurons are structurally unique and have dendrites and axons that are vulnerable to injury. Some neurons in the peripheral nervous system (PNS) can regenerate their axons after injuries. However, most neurons in the central nervous system (CNS) fail to do so, resulting in irreversible neurological disorders. To understand the mechanisms of axon regeneration, various experimental models have been utilized in vivo and in vitro. Here, we collate the key experimental models that revealed the important mechanisms regulating axon regeneration and degeneration in different systems. We also discuss the advantages of experimenting with the rodent model, considering the application of these findings in understanding human diseases and for developing therapeutic methods.
| Original language | English |
|---|---|
| Article number | 474 |
| Pages (from-to) | 1-16 |
| Number of pages | 16 |
| Journal | International journal of molecular sciences |
| Volume | 22 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2021 Jan 2 |
Bibliographical note
Funding Information:Funding: This work has supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT)(NRF-2019R1A2C1005380) and by a Korea University Grant.
Publisher Copyright:
© 2021 by the authors. Li-censee MDPI, Basel, Switzerland.
Keywords
- Animal models
- Axonal regeneration
- Neurodegeneration
ASJC Scopus subject areas
- Catalysis
- Molecular Biology
- Spectroscopy
- Computer Science Applications
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry
