Experimental model systems for understanding human axonal injury responses

Bohm Lee, Yongcheol Cho

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


Neurons are structurally unique and have dendrites and axons that are vulnerable to injury. Some neurons in the peripheral nervous system (PNS) can regenerate their axons after injuries. However, most neurons in the central nervous system (CNS) fail to do so, resulting in irreversible neurological disorders. To understand the mechanisms of axon regeneration, various experimental models have been utilized in vivo and in vitro. Here, we collate the key experimental models that revealed the important mechanisms regulating axon regeneration and degeneration in different systems. We also discuss the advantages of experimenting with the rodent model, considering the application of these findings in understanding human diseases and for developing therapeutic methods.

Original languageEnglish
Article number474
Pages (from-to)1-16
Number of pages16
JournalInternational journal of molecular sciences
Issue number2
Publication statusPublished - 2021 Jan 2

Bibliographical note

Funding Information:
Funding: This work has supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT)(NRF-2019R1A2C1005380) and by a Korea University Grant.

Publisher Copyright:
© 2021 by the authors. Li-censee MDPI, Basel, Switzerland.


  • Animal models
  • Axonal regeneration
  • Neurodegeneration

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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