Exposure to ambient air pollution mixture and senescence-associated secretory phenotype proteins among middle-aged and older women

Eunseon Gwak; Ji Won Shin; Sun Young Kim; Jong Tae Lee; Ok Hee Jeon; Seung Ah Choe

doi:10.1016/j.envres.2024.119642

Exposure to ambient air pollution mixture and senescence-associated secretory phenotype proteins among middle-aged and older women

Eunseon Gwak, Ji Won Shin, Sun Young Kim, Jong Tae Lee, Ok Hee Jeon, Seung Ah Choe

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Our study aimed to investigate the impact of environmental exposures, such as ambient air pollutants, on systemic inflammation and cellular senescence in middle-aged and older women. We utilized epidemiological data linked with exposure data of six air pollutants (particulate matters [PM₁₀, PM_2.5], sulphur dioxide [SO₂], nitrogen dioxide [NO₂], carbon monoxide [CO], and ozone [O₃]) and blood samples of 380 peri- and postmenopausal women participants of the Korean Genome and Epidemiology Study. We measured blood high-sensitivity C-reactive protein (hsCRP) and age-related 27 circulatory senescence-associated secretory phenotypes (SASP) produced by senescent cells. We employed single exposure models to explore the general pattern of association between air pollution exposure and proteomic markers. Using quantile g-computation models, we assessed the association of six air pollutant mixtures with hsCRP and SASP proteins. In single-exposure, single-period models, nine out of the 27 SASP proteins including IFN-γ (β = 0.04, 95% CI: 0.01, 0.07 per interquartile range-increase), IL-8 (0.15, 95% CI: 0.09, 0.20), and MIP1α (0.11, 95% CI: 0.04, 0.18) were positively associated with the average level of O₃ over one week. Among the age-related SASP proteins, IFN-γ (0.11, 95% CI: 0.03, 0.20) and IL-8 (0.22, 95% CI: 0.05, 0.39) were positively associated with exposure to air pollutant mixture over one week. The MIP1β was higher with an increasing one-month average concentration of the air pollutant mixture (0.11, 95% CI: 0.00, 0.21). The IL-8 showed consistently positive association with the ambient air pollutant mixture for the exposure periods ranging from one week to one year. O₃ predominantly showed positive weights in the associations between air pollutant mixtures and IL-8. These findings underscore the potential of proteomic indicators as markers for biological aging attributed to short-term air pollution exposure.

Original language	English
Article number	119642
Journal	Environmental Research
Volume	260
DOIs	https://doi.org/10.1016/j.envres.2024.119642
Publication status	Published - 2024 Nov 1

Bibliographical note

Publisher Copyright:
© 2024 Elsevier Inc.

Keywords

Air pollution
Biomarkers
Cellular senescence
Multiple exposure
Women

ASJC Scopus subject areas

Biochemistry
General Environmental Science

Access to Document

10.1016/j.envres.2024.119642

Cite this

@article{27d050b59de54d0fbe965c64a48cbd6b,

title = "Exposure to ambient air pollution mixture and senescence-associated secretory phenotype proteins among middle-aged and older women",

abstract = "Our study aimed to investigate the impact of environmental exposures, such as ambient air pollutants, on systemic inflammation and cellular senescence in middle-aged and older women. We utilized epidemiological data linked with exposure data of six air pollutants (particulate matters [PM10, PM2.5], sulphur dioxide [SO2], nitrogen dioxide [NO2], carbon monoxide [CO], and ozone [O3]) and blood samples of 380 peri- and postmenopausal women participants of the Korean Genome and Epidemiology Study. We measured blood high-sensitivity C-reactive protein (hsCRP) and age-related 27 circulatory senescence-associated secretory phenotypes (SASP) produced by senescent cells. We employed single exposure models to explore the general pattern of association between air pollution exposure and proteomic markers. Using quantile g-computation models, we assessed the association of six air pollutant mixtures with hsCRP and SASP proteins. In single-exposure, single-period models, nine out of the 27 SASP proteins including IFN-γ (β = 0.04, 95\% CI: 0.01, 0.07 per interquartile range-increase), IL-8 (0.15, 95\% CI: 0.09, 0.20), and MIP1α (0.11, 95\% CI: 0.04, 0.18) were positively associated with the average level of O3 over one week. Among the age-related SASP proteins, IFN-γ (0.11, 95\% CI: 0.03, 0.20) and IL-8 (0.22, 95\% CI: 0.05, 0.39) were positively associated with exposure to air pollutant mixture over one week. The MIP1β was higher with an increasing one-month average concentration of the air pollutant mixture (0.11, 95\% CI: 0.00, 0.21). The IL-8 showed consistently positive association with the ambient air pollutant mixture for the exposure periods ranging from one week to one year. O3 predominantly showed positive weights in the associations between air pollutant mixtures and IL-8. These findings underscore the potential of proteomic indicators as markers for biological aging attributed to short-term air pollution exposure.",

keywords = "Air pollution, Biomarkers, Cellular senescence, Multiple exposure, Women",

author = "Eunseon Gwak and Shin, \{Ji Won\} and Kim, \{Sun Young\} and Lee, \{Jong Tae\} and Jeon, \{Ok Hee\} and Choe, \{Seung Ah\}",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Inc.",

year = "2024",

month = nov,

day = "1",

doi = "10.1016/j.envres.2024.119642",

language = "English",

volume = "260",

journal = "Environmental Research",

issn = "0013-9351",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Exposure to ambient air pollution mixture and senescence-associated secretory phenotype proteins among middle-aged and older women

AU - Gwak, Eunseon

AU - Shin, Ji Won

AU - Kim, Sun Young

AU - Lee, Jong Tae

AU - Jeon, Ok Hee

AU - Choe, Seung Ah

PY - 2024/11/1

Y1 - 2024/11/1

N2 - Our study aimed to investigate the impact of environmental exposures, such as ambient air pollutants, on systemic inflammation and cellular senescence in middle-aged and older women. We utilized epidemiological data linked with exposure data of six air pollutants (particulate matters [PM10, PM2.5], sulphur dioxide [SO2], nitrogen dioxide [NO2], carbon monoxide [CO], and ozone [O3]) and blood samples of 380 peri- and postmenopausal women participants of the Korean Genome and Epidemiology Study. We measured blood high-sensitivity C-reactive protein (hsCRP) and age-related 27 circulatory senescence-associated secretory phenotypes (SASP) produced by senescent cells. We employed single exposure models to explore the general pattern of association between air pollution exposure and proteomic markers. Using quantile g-computation models, we assessed the association of six air pollutant mixtures with hsCRP and SASP proteins. In single-exposure, single-period models, nine out of the 27 SASP proteins including IFN-γ (β = 0.04, 95% CI: 0.01, 0.07 per interquartile range-increase), IL-8 (0.15, 95% CI: 0.09, 0.20), and MIP1α (0.11, 95% CI: 0.04, 0.18) were positively associated with the average level of O3 over one week. Among the age-related SASP proteins, IFN-γ (0.11, 95% CI: 0.03, 0.20) and IL-8 (0.22, 95% CI: 0.05, 0.39) were positively associated with exposure to air pollutant mixture over one week. The MIP1β was higher with an increasing one-month average concentration of the air pollutant mixture (0.11, 95% CI: 0.00, 0.21). The IL-8 showed consistently positive association with the ambient air pollutant mixture for the exposure periods ranging from one week to one year. O3 predominantly showed positive weights in the associations between air pollutant mixtures and IL-8. These findings underscore the potential of proteomic indicators as markers for biological aging attributed to short-term air pollution exposure.

AB - Our study aimed to investigate the impact of environmental exposures, such as ambient air pollutants, on systemic inflammation and cellular senescence in middle-aged and older women. We utilized epidemiological data linked with exposure data of six air pollutants (particulate matters [PM10, PM2.5], sulphur dioxide [SO2], nitrogen dioxide [NO2], carbon monoxide [CO], and ozone [O3]) and blood samples of 380 peri- and postmenopausal women participants of the Korean Genome and Epidemiology Study. We measured blood high-sensitivity C-reactive protein (hsCRP) and age-related 27 circulatory senescence-associated secretory phenotypes (SASP) produced by senescent cells. We employed single exposure models to explore the general pattern of association between air pollution exposure and proteomic markers. Using quantile g-computation models, we assessed the association of six air pollutant mixtures with hsCRP and SASP proteins. In single-exposure, single-period models, nine out of the 27 SASP proteins including IFN-γ (β = 0.04, 95% CI: 0.01, 0.07 per interquartile range-increase), IL-8 (0.15, 95% CI: 0.09, 0.20), and MIP1α (0.11, 95% CI: 0.04, 0.18) were positively associated with the average level of O3 over one week. Among the age-related SASP proteins, IFN-γ (0.11, 95% CI: 0.03, 0.20) and IL-8 (0.22, 95% CI: 0.05, 0.39) were positively associated with exposure to air pollutant mixture over one week. The MIP1β was higher with an increasing one-month average concentration of the air pollutant mixture (0.11, 95% CI: 0.00, 0.21). The IL-8 showed consistently positive association with the ambient air pollutant mixture for the exposure periods ranging from one week to one year. O3 predominantly showed positive weights in the associations between air pollutant mixtures and IL-8. These findings underscore the potential of proteomic indicators as markers for biological aging attributed to short-term air pollution exposure.

KW - Air pollution

KW - Biomarkers

KW - Cellular senescence

KW - Multiple exposure

KW - Women

UR - http://www.scopus.com/inward/record.url?scp=85199282970&partnerID=8YFLogxK

U2 - 10.1016/j.envres.2024.119642

DO - 10.1016/j.envres.2024.119642

M3 - Article

C2 - 39029725

AN - SCOPUS:85199282970

SN - 0013-9351

VL - 260

JO - Environmental Research

JF - Environmental Research

M1 - 119642

ER -

Exposure to ambient air pollution mixture and senescence-associated secretory phenotype proteins among middle-aged and older women

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this