Expression of estrogen receptors in gastric cancer and their clinical significance

Woo Sang Ryu, Jong Han Kim, You Jin Jang, Sung Soo Park, Jun Won Um, Seong Heum Park, Seung Joo Kim, Young Jae Mok, Chong Suk Kim

    Research output: Contribution to journalArticlepeer-review

    68 Citations (Scopus)


    Backgrounds and Objectives The male predominance of gastric cancer suggests that female sex hormones may have a protective effect against gastric cancer. We evaluated the expression of estrogen receptors in gastric cancer tissue and cells and the clinical significance of ER-β expression in gastric cancer. Method ER-α, ER-β proteins extracted from normal stomach, gastric cancer tissues, and cultured gastric cancer cells (KATO-III, mkn28, mkn45, and mkn74) were assessed by Western blot analysis. The clinical significance of ER-β was explored using tissue microarray methods and immunohistochemical staining of specimens from 148 gastric cancers. Results Both ER-α and β protein expression were noted in normal and gastric cancer tissues. However, in cultured gastric cells, only ER-β was noted in mkn28 and mkn74. Of 148 gastric cancers, 67 (45.3%) were ER-β positive. The ER-β positive group was associated with lower tumor stage, Lauren's intestinal type, negative perineural invasion, and free of recurrence. The ER-β positive group had a better 3-year survival compared with the negative group in survival analysis. Conclusion Our results suggest that the presence of ER-β in gastric cancer could have a protective effect against invasiveness of gastric cancer. Further studies are needed to clarify the role of ER-β in gastric cancers. J. Surg. Oncol. 2012; 106:456-461. © 2012 Wiley Periodicals, Inc.

    Original languageEnglish
    Pages (from-to)456-461
    Number of pages6
    JournalJournal of Surgical Oncology
    Issue number4
    Publication statusPublished - 2012 Sept 15


    • estrogen receptor α
    • estrogen receptor β
    • gastric cancer

    ASJC Scopus subject areas

    • Surgery
    • Oncology


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