TY - JOUR
T1 - Expression of mRNA of trefoil factor peptides in human nasal mucosa
AU - See Hag Lee, Hag Lee
AU - Seung Hoon Lee, Hoon Lee
AU - Byung Hoon Oh, Hoon Oh
AU - Heung Man Lee, Man Lee
AU - Jong Ouck Choi, Ouck Choi
AU - Kwang Yoon Jung, Yoon Jung
PY - 2001
Y1 - 2001
N2 - Trefoil factor family (TFF) peptides are typical secretory products of gastrointestinal mucus epithelia. Three TFF peptides exist in humans, TFF1 (formerly pS2), TFF2 (formerly hSP) and TFF3 (formerly hP1B/hITF), acting as link peptides and influencing the rheological properties of mucous gels. The combined actions of TFF peptides and mucins have been shown to provide significant protection to mucosal surfaces. In this respect, TFF peptides may play a key role in the maintenance of the surface integrity of nasal mucosa. The present study aimed to investigate the expression of mRNA of TFF peptides in human inferior turbinate mucosa using reverse transcription polymerase chain reaction and in situ hybridization. TFF1 and TFF3 mRNA were detected in the human turbinate tissues examined. In contrast, TFF2 mRNA was not expressed in any samples. Using in situ hybridization, TFF1 and TFF3 mRNA were predominantly localized in epithelial cells and submucosal glandular epithelium. These data suggest that nasal epithelia and submucosal glands may secrete TFF1 and TFF3, contributing to the stabilization of the mucous lining of human nasal mucosa.
AB - Trefoil factor family (TFF) peptides are typical secretory products of gastrointestinal mucus epithelia. Three TFF peptides exist in humans, TFF1 (formerly pS2), TFF2 (formerly hSP) and TFF3 (formerly hP1B/hITF), acting as link peptides and influencing the rheological properties of mucous gels. The combined actions of TFF peptides and mucins have been shown to provide significant protection to mucosal surfaces. In this respect, TFF peptides may play a key role in the maintenance of the surface integrity of nasal mucosa. The present study aimed to investigate the expression of mRNA of TFF peptides in human inferior turbinate mucosa using reverse transcription polymerase chain reaction and in situ hybridization. TFF1 and TFF3 mRNA were detected in the human turbinate tissues examined. In contrast, TFF2 mRNA was not expressed in any samples. Using in situ hybridization, TFF1 and TFF3 mRNA were predominantly localized in epithelial cells and submucosal glandular epithelium. These data suggest that nasal epithelia and submucosal glands may secrete TFF1 and TFF3, contributing to the stabilization of the mucous lining of human nasal mucosa.
KW - Inferior turbinate mucosa
KW - TFF1
KW - TFF3
UR - http://www.scopus.com/inward/record.url?scp=0035160883&partnerID=8YFLogxK
U2 - 10.1080/00016480152602320
DO - 10.1080/00016480152602320
M3 - Article
C2 - 11718251
AN - SCOPUS:0035160883
SN - 0001-6489
VL - 121
SP - 849
EP - 853
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
IS - 7
ER -