Expression pattern and functional role of Phc2 during activation of helper T cells after antigenic stimulation

Kyu Won Cho; Joonbeom Bae; Suk Jun Lee; Taehoon Chun

doi:10.1007/s11626-013-9618-0

Expression pattern and functional role of Phc2 during activation of helper T cells after antigenic stimulation

Kyu Won Cho, Joonbeom Bae, Suk Jun Lee, Taehoon Chun

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Polycomb group (PcG) proteins, which are conserved from invertebrates to mammals, are associated with epigenetic regulation of many cell fates. The activities of PcG proteins are largely associated with modulation of specific immune reactions. However, no study has attempted to explore the role of Phc2, a subunit of polycomb repressive complex 1, on helper T (Th) cell activation. Presently, Phc2 expression was down-regulated in activated Th cells. The ectopic expression of Phc2 in Th cells inhibited Th cell proliferation and secretion of interleukin-2 from Th cells upon antigen-specific activation. Phc2 may act as a negative regulator that inhibits the activity of Th cells.

Original language	English
Pages (from-to)	360-370
Number of pages	11
Journal	In Vitro Cellular and Developmental Biology - Animal
Volume	49
Issue number	5
DOIs	https://doi.org/10.1007/s11626-013-9618-0
Publication status	Published - 2013 May

Keywords

Cell proliferation
Helper T cell
IL-2
Phc2
Polycomb repressive complex 1

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1007/s11626-013-9618-0

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title = "Expression pattern and functional role of Phc2 during activation of helper T cells after antigenic stimulation",

abstract = "Polycomb group (PcG) proteins, which are conserved from invertebrates to mammals, are associated with epigenetic regulation of many cell fates. The activities of PcG proteins are largely associated with modulation of specific immune reactions. However, no study has attempted to explore the role of Phc2, a subunit of polycomb repressive complex 1, on helper T (Th) cell activation. Presently, Phc2 expression was down-regulated in activated Th cells. The ectopic expression of Phc2 in Th cells inhibited Th cell proliferation and secretion of interleukin-2 from Th cells upon antigen-specific activation. Phc2 may act as a negative regulator that inhibits the activity of Th cells.",

keywords = "Cell proliferation, Helper T cell, IL-2, Phc2, Polycomb repressive complex 1",

author = "Cho, {Kyu Won} and Joonbeom Bae and Lee, {Suk Jun} and Taehoon Chun",

note = "Funding Information: Acknowledgments This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2010-0023283). This work was also supported by Next-Generation BioGreen 21 program (No. PJ008089), Rural Development Administration, Republic of Korea.",

year = "2013",

month = may,

doi = "10.1007/s11626-013-9618-0",

language = "English",

volume = "49",

pages = "360--370",

journal = "In Vitro Cellular and Developmental Biology - Animal",

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TY - JOUR

T1 - Expression pattern and functional role of Phc2 during activation of helper T cells after antigenic stimulation

AU - Cho, Kyu Won

AU - Bae, Joonbeom

AU - Lee, Suk Jun

AU - Chun, Taehoon

N1 - Funding Information: Acknowledgments This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2010-0023283). This work was also supported by Next-Generation BioGreen 21 program (No. PJ008089), Rural Development Administration, Republic of Korea.

PY - 2013/5

Y1 - 2013/5

N2 - Polycomb group (PcG) proteins, which are conserved from invertebrates to mammals, are associated with epigenetic regulation of many cell fates. The activities of PcG proteins are largely associated with modulation of specific immune reactions. However, no study has attempted to explore the role of Phc2, a subunit of polycomb repressive complex 1, on helper T (Th) cell activation. Presently, Phc2 expression was down-regulated in activated Th cells. The ectopic expression of Phc2 in Th cells inhibited Th cell proliferation and secretion of interleukin-2 from Th cells upon antigen-specific activation. Phc2 may act as a negative regulator that inhibits the activity of Th cells.

AB - Polycomb group (PcG) proteins, which are conserved from invertebrates to mammals, are associated with epigenetic regulation of many cell fates. The activities of PcG proteins are largely associated with modulation of specific immune reactions. However, no study has attempted to explore the role of Phc2, a subunit of polycomb repressive complex 1, on helper T (Th) cell activation. Presently, Phc2 expression was down-regulated in activated Th cells. The ectopic expression of Phc2 in Th cells inhibited Th cell proliferation and secretion of interleukin-2 from Th cells upon antigen-specific activation. Phc2 may act as a negative regulator that inhibits the activity of Th cells.

KW - Cell proliferation

KW - Helper T cell

KW - IL-2

KW - Phc2

KW - Polycomb repressive complex 1

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DO - 10.1007/s11626-013-9618-0

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SN - 1071-2690

VL - 49

SP - 360

EP - 370

JO - In Vitro Cellular and Developmental Biology - Animal

JF - In Vitro Cellular and Developmental Biology - Animal

IS - 5

ER -

Expression pattern and functional role of Phc2 during activation of helper T cells after antigenic stimulation

Abstract

Keywords

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