TY - JOUR
T1 - Extended use of systemic steroid is beneficial in preserving hearing in guinea pigs after cochlear implant
AU - Rah, Yoon Chan
AU - Lee, Min Young
AU - Kim, Shin Hye
AU - Kim, Doo Hee
AU - Eastwood, Hayden
AU - O'Leary, Stephen J.
AU - Lee, Jun Ho
N1 - Publisher Copyright:
© 2016 Acta Oto-Laryngologica AB (Ltd).
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Conclusion: Seven-day administration of systemic steroids was more effective in preserving hearing for 12 weeks after cochlear implantation (CI) than a 3-day delivery. Objectives: To determine the effectiveness of extended delivery of systemic steroids to preserve hearing in guinea pigs after CI. Methods: Dexamethasone (4 mg/ml) was delivered parenterally via a mini-osmotic pump for either 3 or 7 days. A dummy CI electrode was inserted via cochleostomy approach in 8-week-old guinea pigs. Auditory thresholds were assessed from tone burst auditory brainstem responses (2, 8, 16, 24, and 32 kHz) at 1 day prior to CI, and 1, 4, and 12 weeks after implantation. Histologic evaluation of the cochleae was carried out. Results: No differences were observed in hearing thresholds among groups before CI. Significant hearing preservation was achieved at 8, 16, 24, and 32 kHz only in the 7-day infusion group compared with the control group at 1 week after CI. The same trend was maintained at 4 weeks (16, 24 kHz) and 12 weeks (16, 24, and 32 kHz). Histologic review of the 7-day infusion group revealed less fibrosis and ossification in the scala tympani and the preservation of more spiral ganglion cells, compared with the control group.
AB - Conclusion: Seven-day administration of systemic steroids was more effective in preserving hearing for 12 weeks after cochlear implantation (CI) than a 3-day delivery. Objectives: To determine the effectiveness of extended delivery of systemic steroids to preserve hearing in guinea pigs after CI. Methods: Dexamethasone (4 mg/ml) was delivered parenterally via a mini-osmotic pump for either 3 or 7 days. A dummy CI electrode was inserted via cochleostomy approach in 8-week-old guinea pigs. Auditory thresholds were assessed from tone burst auditory brainstem responses (2, 8, 16, 24, and 32 kHz) at 1 day prior to CI, and 1, 4, and 12 weeks after implantation. Histologic evaluation of the cochleae was carried out. Results: No differences were observed in hearing thresholds among groups before CI. Significant hearing preservation was achieved at 8, 16, 24, and 32 kHz only in the 7-day infusion group compared with the control group at 1 week after CI. The same trend was maintained at 4 weeks (16, 24 kHz) and 12 weeks (16, 24, and 32 kHz). Histologic review of the 7-day infusion group revealed less fibrosis and ossification in the scala tympani and the preservation of more spiral ganglion cells, compared with the control group.
KW - Cochlear implant
KW - hearing loss
KW - steroid
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U2 - 10.1080/00016489.2016.1206965
DO - 10.1080/00016489.2016.1206965
M3 - Article
C2 - 27466708
AN - SCOPUS:84979987496
SN - 0001-6489
VL - 136
SP - 1213
EP - 1219
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
IS - 12
ER -