Extracellular RNAs (exRNAs) are a type of RNA molecules that present in various biological fluids. exRNAs are heterogenous populations including small (e.g., miRNA) and long non-coding RNAs and coding RNAs (e.g., mRNA). They can exist in a free form or associate with carriers range from lipo- and ribo-proteins to extracellular vesicles such as exosomes in the extracellular fluids. exRNAs participate in cell-to-cell communication to regulate a broad array of physiological and pathological processes. exRNAs have been widely studied as a biomarker for cancer and other diseases. In this review, we will discuss the sorts of exRNAs with potential carriers as well as their roles in cancer.
Bibliographical noteFunding Information:
This work was supported by the National Research Foundation of Korea Government NRF-2020R1F1A1071579 (YJ. Jeon) and 2020R1C1C1009921 (O. H. Jeon).
© 2020 Elsevier B.V.
ASJC Scopus subject areas
- Cancer Research