Abstract
Extracellular vesicles (EVs), naturally secreted by cells, act as mediators for communication between cells. They are transported to the recipient cells along with cargoes such as nucleic acids, proteins, and lipids that reflect the changes occurring within the parent cells. Thus, EVs have been recognized as potential theranostic agents for diagnosis, treatment, and prognosis. In particular, the evidence accumulated to date suggests an important role of EVs in the initiation and progression of skin aging and various skin diseases, including psoriasis, systemic lupus erythematosus, vitiligo, and chronic wounds. This review highlights recent research that investigates the role of EVs and their potential as biomarkers and therapeutic agents for skin diseases and aging.
| Original language | English |
|---|---|
| Article number | 760 |
| Journal | Pharmaceutics |
| Volume | 13 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2021 May |
Bibliographical note
Funding Information:This work was supported by the Mid-career Researcher Program (NRF-2019R1A2C2010408) and the Intramural Research Program of Korea Institute of Science and Technology (KIST).
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords
- Biomarker
- Extracellular vesicles
- Skin aging
- Skin disease
- Therapy
ASJC Scopus subject areas
- Pharmaceutical Science