Extracellular vesicles as potential therapeutics for inflammatory diseases

Hee Sook Hwang, Hyosuk Kim, Geonhee Han, Jong Won Lee, Kwangmeyung Kim, Ick Chan Kwon, Yoosoo Yang, Sun Hwa Kim

    Research output: Contribution to journalReview articlepeer-review

    26 Citations (Scopus)

    Abstract

    Extracellular vesicles (EV) deliver cargoes such as nucleic acids, proteins, and lipids between cells and serve as an intercellular communicator. As it is revealed that most of the functions associated to EVs are closely related to the immune response, the important role of EVs in inflammatory diseases is emerging. EVs can be functionalized through EV surface engineering and endow targeting moiety that allows for the target specificity for therapeutic applications in inflammatory diseases. Moreover, engineered EVs are considered as promising nanoparticles to develop personalized therapeutic carriers. In this review, we highlight the role of EVs in various inflammatory diseases, the application of EV as anti-inflammatory therapeutics, and the current state of the art in EV engineering techniques.

    Original languageEnglish
    Article number5487
    JournalInternational journal of molecular sciences
    Volume22
    Issue number11
    DOIs
    Publication statusPublished - 2021 Jun 1

    Bibliographical note

    Funding Information:
    This study was supported by the Mid-career Researcher Program (NRF-2019R1A2C2010408), Brain Pool Program (NRF-2020H1D3A1A02081401) and Intramural Research Program of Korea Institute of Science and Technology (KIST).

    Publisher Copyright:
    © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

    Keywords

    • Biomarker
    • EV engineering
    • Extracellular vesicle
    • Inflammatory disease

    ASJC Scopus subject areas

    • Catalysis
    • Molecular Biology
    • Spectroscopy
    • Computer Science Applications
    • Physical and Theoretical Chemistry
    • Organic Chemistry
    • Inorganic Chemistry

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