Extracellular vesicles as potential therapeutics for inflammatory diseases

Hee Sook Hwang; Hyosuk Kim; Geonhee Han; Jong Won Lee; Kwangmeyung Kim; Ick Chan Kwon; Yoosoo Yang; Sun Hwa Kim

doi:10.3390/ijms22115487

Extracellular vesicles as potential therapeutics for inflammatory diseases

Hee Sook Hwang, Hyosuk Kim, Geonhee Han, Jong Won Lee, Kwangmeyung Kim, Ick Chan Kwon, Yoosoo Yang, Sun Hwa Kim

Research output: Contribution to journal › Review article › peer-review

26 Citations (Scopus)

Abstract

Extracellular vesicles (EV) deliver cargoes such as nucleic acids, proteins, and lipids between cells and serve as an intercellular communicator. As it is revealed that most of the functions associated to EVs are closely related to the immune response, the important role of EVs in inflammatory diseases is emerging. EVs can be functionalized through EV surface engineering and endow targeting moiety that allows for the target specificity for therapeutic applications in inflammatory diseases. Moreover, engineered EVs are considered as promising nanoparticles to develop personalized therapeutic carriers. In this review, we highlight the role of EVs in various inflammatory diseases, the application of EV as anti-inflammatory therapeutics, and the current state of the art in EV engineering techniques.

Original language	English
Article number	5487
Journal	International journal of molecular sciences
Volume	22
Issue number	11
DOIs	https://doi.org/10.3390/ijms22115487
Publication status	Published - 2021 Jun 1

Bibliographical note

Funding Information:
This study was supported by the Mid-career Researcher Program (NRF-2019R1A2C2010408), Brain Pool Program (NRF-2020H1D3A1A02081401) and Intramural Research Program of Korea Institute of Science and Technology (KIST).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Biomarker
EV engineering
Extracellular vesicle
Inflammatory disease

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms22115487

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title = "Extracellular vesicles as potential therapeutics for inflammatory diseases",

abstract = "Extracellular vesicles (EV) deliver cargoes such as nucleic acids, proteins, and lipids between cells and serve as an intercellular communicator. As it is revealed that most of the functions associated to EVs are closely related to the immune response, the important role of EVs in inflammatory diseases is emerging. EVs can be functionalized through EV surface engineering and endow targeting moiety that allows for the target specificity for therapeutic applications in inflammatory diseases. Moreover, engineered EVs are considered as promising nanoparticles to develop personalized therapeutic carriers. In this review, we highlight the role of EVs in various inflammatory diseases, the application of EV as anti-inflammatory therapeutics, and the current state of the art in EV engineering techniques.",

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author = "Hwang, {Hee Sook} and Hyosuk Kim and Geonhee Han and Lee, {Jong Won} and Kwangmeyung Kim and Kwon, {Ick Chan} and Yoosoo Yang and Kim, {Sun Hwa}",

note = "Funding Information: This study was supported by the Mid-career Researcher Program (NRF-2019R1A2C2010408), Brain Pool Program (NRF-2020H1D3A1A02081401) and Intramural Research Program of Korea Institute of Science and Technology (KIST). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Hwang, Hee Sook

AU - Kim, Hyosuk

AU - Han, Geonhee

AU - Lee, Jong Won

AU - Kim, Kwangmeyung

AU - Kwon, Ick Chan

AU - Yang, Yoosoo

AU - Kim, Sun Hwa

N1 - Funding Information: This study was supported by the Mid-career Researcher Program (NRF-2019R1A2C2010408), Brain Pool Program (NRF-2020H1D3A1A02081401) and Intramural Research Program of Korea Institute of Science and Technology (KIST). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/6/1

Y1 - 2021/6/1

N2 - Extracellular vesicles (EV) deliver cargoes such as nucleic acids, proteins, and lipids between cells and serve as an intercellular communicator. As it is revealed that most of the functions associated to EVs are closely related to the immune response, the important role of EVs in inflammatory diseases is emerging. EVs can be functionalized through EV surface engineering and endow targeting moiety that allows for the target specificity for therapeutic applications in inflammatory diseases. Moreover, engineered EVs are considered as promising nanoparticles to develop personalized therapeutic carriers. In this review, we highlight the role of EVs in various inflammatory diseases, the application of EV as anti-inflammatory therapeutics, and the current state of the art in EV engineering techniques.

AB - Extracellular vesicles (EV) deliver cargoes such as nucleic acids, proteins, and lipids between cells and serve as an intercellular communicator. As it is revealed that most of the functions associated to EVs are closely related to the immune response, the important role of EVs in inflammatory diseases is emerging. EVs can be functionalized through EV surface engineering and endow targeting moiety that allows for the target specificity for therapeutic applications in inflammatory diseases. Moreover, engineered EVs are considered as promising nanoparticles to develop personalized therapeutic carriers. In this review, we highlight the role of EVs in various inflammatory diseases, the application of EV as anti-inflammatory therapeutics, and the current state of the art in EV engineering techniques.

KW - Biomarker

KW - EV engineering

KW - Extracellular vesicle

KW - Inflammatory disease

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U2 - 10.3390/ijms22115487

DO - 10.3390/ijms22115487

M3 - Review article

C2 - 34067503

AN - SCOPUS:85106047733

SN - 1661-6596

VL - 22

JO - International journal of molecular sciences

JF - International journal of molecular sciences

IS - 11

M1 - 5487

ER -

Extracellular vesicles as potential therapeutics for inflammatory diseases

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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