Fabrication of electrospun antioxidant nanofibers by rutin-pluronic solid dispersions for enhanced solubility

Il Woo Lee, Jinglei Li, Xiguang Chen, Hyun Jin Park

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)

    Abstract

    In this study, solid dispersions (SDs) and electrospinning combined methods were used to increase the bioavailability and solubility of a water insoluble drug. Pullulan (PUL) nanofibers containing rutin-Pluronic SDs (PUL&RU@PF) were fabricated by electrospinning. Rutin was efficiently loaded with Pluronic SDs using a facile mixing method and the prepared SDs indicated that 4% w/v Pluronic concentration provided the optimal drug loading efficiency. Scanning electron microscopy (SEM) verified that the morphology of the complex nanofibers had a uniformly smooth surface with a porous structure. The amorphous state of rutin was examined by XRD and DSC. Moreover, rutin in the electrospun PUL-rutin-Pluronic complex structure displayed a fast release profile and equivalent antioxidant ability compared to that of raw rutin. In conclusion, PUL&RU@PF may be a promising alternative for enhanced solubility and UV stability with remaining rutin's inherent antioxidant ability.

    Original languageEnglish
    Article number44859
    JournalJournal of Applied Polymer Science
    Volume134
    Issue number21
    DOIs
    Publication statusPublished - 2017 Jun 5

    Bibliographical note

    Publisher Copyright:
    © 2017 Wiley Periodicals, Inc.

    Keywords

    • drug delivery systems
    • electrospinning
    • hydrophilic polymers
    • polysaccharides

    ASJC Scopus subject areas

    • General Chemistry
    • Surfaces, Coatings and Films
    • Polymers and Plastics
    • Materials Chemistry

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