Abstract
In this study, solid dispersions (SDs) and electrospinning combined methods were used to increase the bioavailability and solubility of a water insoluble drug. Pullulan (PUL) nanofibers containing rutin-Pluronic SDs (PUL&RU@PF) were fabricated by electrospinning. Rutin was efficiently loaded with Pluronic SDs using a facile mixing method and the prepared SDs indicated that 4% w/v Pluronic concentration provided the optimal drug loading efficiency. Scanning electron microscopy (SEM) verified that the morphology of the complex nanofibers had a uniformly smooth surface with a porous structure. The amorphous state of rutin was examined by XRD and DSC. Moreover, rutin in the electrospun PUL-rutin-Pluronic complex structure displayed a fast release profile and equivalent antioxidant ability compared to that of raw rutin. In conclusion, PUL&RU@PF may be a promising alternative for enhanced solubility and UV stability with remaining rutin's inherent antioxidant ability.
Original language | English |
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Article number | 44859 |
Journal | Journal of Applied Polymer Science |
Volume | 134 |
Issue number | 21 |
DOIs | |
Publication status | Published - 2017 Jun 5 |
Keywords
- drug delivery systems
- electrospinning
- hydrophilic polymers
- polysaccharides
ASJC Scopus subject areas
- Chemistry(all)
- Surfaces, Coatings and Films
- Polymers and Plastics
- Materials Chemistry