Fabrication of Multi-layered Macroscopic Hydrogel Scaffold Composed of Multiple Components by Precise Control of UV Energy

Donghyeon Roh, Woongsun Choi, Junbeom Kim, Hyun Yong Yu, Nakwon Choi, Il Joo Cho

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Hydrogel scaffolds composed of multiple components are promising platform in tissue engineering as a transplantation materials or artificial organs. Here, we present a new fabrication method for implementing multi-layered macroscopic hydrogel scaffold composed of multiple components by controlling height of hydrogel layer through precise control of ultraviolet (UV) energy density. Through the repetition of the photolithography process with energy control, we can form several layers of hydrogel with different height. We characterized UV energy-dependent profiles with single-layered PEGDA posts photocrosslinked by the modular methodology and examined the optical effect on the fabrication of multi-layered, macroscopic hydrogel structure. Finally, we successfully demonstrated the potential applicability of our approach by fabricating various macroscopic hydrogel constructs composed of multiple hydrogel layers.

Original languageEnglish
Pages (from-to)280-286
Number of pages7
JournalBiochip Journal
Volume12
Issue number4
DOIs
Publication statusPublished - 2018 Dec 1
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgements This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (no. NRF-2017M3A9B30 61319).

Publisher Copyright:
© 2018, The Korean BioChip Society and Springer-Verlag GmbH Germany, part of Springer Nature.

Keywords

  • Artificial tissues/organs
  • Height control via UV energy density
  • Incorporation of multiple components
  • Macroscopic hydrogel scaffold
  • Multilayered structures
  • Photocrosslinking
  • Tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Electrical and Electronic Engineering

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