Abstract
This paper describes the esterification of aromatic and aliphatic alcohols by using 2-acyl-4,5-dichloropyridazin-3(2H)-ones as an acyl source under Friedel-Crafts conditions. Twelve alcohols were reacted with four 2-acyl-4,5-dichloropyridazin-3(2H)-ones in the presence of AlCl3 in tetrahydrofuran at room temperature to give the corresponding esters in moderate to excellent yields. Thus, 2-acylpyridazin-3(2H)-ones serve as good and atom-economic acyl sources for the esterification of aromatic alcohols under Friedel-Crafts conditions, representing a rapid, practical, and efficient method of esterification.
Original language | English |
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Article number | st-2014-u0361-l |
Pages (from-to) | 1909-1915 |
Number of pages | 7 |
Journal | Synlett |
Volume | 25 |
Issue number | 13 |
DOIs | |
Publication status | Published - 2014 Aug |
Keywords
- Friedel-Crafts condition
- acylation
- esterification
- sustainable chemistry
- synthetic methods
ASJC Scopus subject areas
- Organic Chemistry