Facilely fabricating PCL nanofibrous scaffolds with hierarchical pore structure for tissue engineering

Yuzhang Du, Xiaofeng Chen, Young Hag Koh, Bo Lei

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Highly hierarchical pore structure (macro-micro-nano) for biomimetic nanofibrous scaffolds could efficiently enhance cell infiltration and tissue formation. However, it is difficult to prepare these structures by using traditional electrostatic spinning techniques. Here, we report a facile method to fabricate polycaprolactone (PCL) nanofibrous scaffolds with multi-scale pore structure by simple phase separation. By employing water-dioxane as solvents and tris spheres as macropore template, PCL nanofibrous scaffolds with pores 300-800 μm, 1-10 μm and 100-1000 nm in diameter can be facilely produced. All scaffolds possess controlled nanofibrous morphology and porosity (90-98%). This scaffold may provide promising applications in tissue engineering and drug delivery.

Original languageEnglish
Pages (from-to)62-65
Number of pages4
JournalMaterials Letters
Publication statusPublished - 2014 May 1

Bibliographical note

Funding Information:
We acknowledge the valuable comments of potential reviewers. This work was supported by the Scientific Research Starting Foundation from Xi’an Jiaotong University , the National Natural Science Foundation of China ( 51072055 ), and the National 973 Project of China ( 2011CB606204 ).


  • Biomaterials
  • Hierarchical pores
  • Nanofibrous scaffolds
  • Phase separation
  • Porous materials

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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