Abstract
Highly hierarchical pore structure (macro-micro-nano) for biomimetic nanofibrous scaffolds could efficiently enhance cell infiltration and tissue formation. However, it is difficult to prepare these structures by using traditional electrostatic spinning techniques. Here, we report a facile method to fabricate polycaprolactone (PCL) nanofibrous scaffolds with multi-scale pore structure by simple phase separation. By employing water-dioxane as solvents and tris spheres as macropore template, PCL nanofibrous scaffolds with pores 300-800 μm, 1-10 μm and 100-1000 nm in diameter can be facilely produced. All scaffolds possess controlled nanofibrous morphology and porosity (90-98%). This scaffold may provide promising applications in tissue engineering and drug delivery.
Original language | English |
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Pages (from-to) | 62-65 |
Number of pages | 4 |
Journal | Materials Letters |
Volume | 122 |
DOIs | |
Publication status | Published - 2014 May 1 |
Bibliographical note
Funding Information:We acknowledge the valuable comments of potential reviewers. This work was supported by the Scientific Research Starting Foundation from Xi’an Jiaotong University , the National Natural Science Foundation of China ( 51072055 ), and the National 973 Project of China ( 2011CB606204 ).
Keywords
- Biomaterials
- Hierarchical pores
- Nanofibrous scaffolds
- Phase separation
- Porous materials
ASJC Scopus subject areas
- General Materials Science
- Condensed Matter Physics
- Mechanics of Materials
- Mechanical Engineering