Facilely fabricating PCL nanofibrous scaffolds with hierarchical pore structure for tissue engineering

Yuzhang Du; Xiaofeng Chen; Young Hag Koh; Bo Lei

doi:10.1016/j.matlet.2014.02.031

Facilely fabricating PCL nanofibrous scaffolds with hierarchical pore structure for tissue engineering

Yuzhang Du, Xiaofeng Chen, Young Hag Koh, Bo Lei

School of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Highly hierarchical pore structure (macro-micro-nano) for biomimetic nanofibrous scaffolds could efficiently enhance cell infiltration and tissue formation. However, it is difficult to prepare these structures by using traditional electrostatic spinning techniques. Here, we report a facile method to fabricate polycaprolactone (PCL) nanofibrous scaffolds with multi-scale pore structure by simple phase separation. By employing water-dioxane as solvents and tris spheres as macropore template, PCL nanofibrous scaffolds with pores 300-800 μm, 1-10 μm and 100-1000 nm in diameter can be facilely produced. All scaffolds possess controlled nanofibrous morphology and porosity (90-98%). This scaffold may provide promising applications in tissue engineering and drug delivery.

Original language	English
Pages (from-to)	62-65
Number of pages	4
Journal	Materials Letters
Volume	122
DOIs	https://doi.org/10.1016/j.matlet.2014.02.031
Publication status	Published - 2014 May 1

Bibliographical note

Funding Information:
We acknowledge the valuable comments of potential reviewers. This work was supported by the Scientific Research Starting Foundation from Xi’an Jiaotong University , the National Natural Science Foundation of China ( 51072055 ), and the National 973 Project of China ( 2011CB606204 ).

Keywords

Biomaterials
Hierarchical pores
Nanofibrous scaffolds
Phase separation
Porous materials

ASJC Scopus subject areas

Materials Science(all)
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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10.1016/j.matlet.2014.02.031

Cite this

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title = "Facilely fabricating PCL nanofibrous scaffolds with hierarchical pore structure for tissue engineering",

abstract = "Highly hierarchical pore structure (macro-micro-nano) for biomimetic nanofibrous scaffolds could efficiently enhance cell infiltration and tissue formation. However, it is difficult to prepare these structures by using traditional electrostatic spinning techniques. Here, we report a facile method to fabricate polycaprolactone (PCL) nanofibrous scaffolds with multi-scale pore structure by simple phase separation. By employing water-dioxane as solvents and tris spheres as macropore template, PCL nanofibrous scaffolds with pores 300-800 μm, 1-10 μm and 100-1000 nm in diameter can be facilely produced. All scaffolds possess controlled nanofibrous morphology and porosity (90-98%). This scaffold may provide promising applications in tissue engineering and drug delivery.",

keywords = "Biomaterials, Hierarchical pores, Nanofibrous scaffolds, Phase separation, Porous materials",

author = "Yuzhang Du and Xiaofeng Chen and {Hag Koh}, Young and Bo Lei",

note = "Funding Information: We acknowledge the valuable comments of potential reviewers. This work was supported by the Scientific Research Starting Foundation from Xi{\textquoteright}an Jiaotong University , the National Natural Science Foundation of China ( 51072055 ), and the National 973 Project of China ( 2011CB606204 ). ",

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AU - Du, Yuzhang

AU - Chen, Xiaofeng

AU - Hag Koh, Young

AU - Lei, Bo

N1 - Funding Information: We acknowledge the valuable comments of potential reviewers. This work was supported by the Scientific Research Starting Foundation from Xi’an Jiaotong University , the National Natural Science Foundation of China ( 51072055 ), and the National 973 Project of China ( 2011CB606204 ).

PY - 2014/5/1

Y1 - 2014/5/1

N2 - Highly hierarchical pore structure (macro-micro-nano) for biomimetic nanofibrous scaffolds could efficiently enhance cell infiltration and tissue formation. However, it is difficult to prepare these structures by using traditional electrostatic spinning techniques. Here, we report a facile method to fabricate polycaprolactone (PCL) nanofibrous scaffolds with multi-scale pore structure by simple phase separation. By employing water-dioxane as solvents and tris spheres as macropore template, PCL nanofibrous scaffolds with pores 300-800 μm, 1-10 μm and 100-1000 nm in diameter can be facilely produced. All scaffolds possess controlled nanofibrous morphology and porosity (90-98%). This scaffold may provide promising applications in tissue engineering and drug delivery.

AB - Highly hierarchical pore structure (macro-micro-nano) for biomimetic nanofibrous scaffolds could efficiently enhance cell infiltration and tissue formation. However, it is difficult to prepare these structures by using traditional electrostatic spinning techniques. Here, we report a facile method to fabricate polycaprolactone (PCL) nanofibrous scaffolds with multi-scale pore structure by simple phase separation. By employing water-dioxane as solvents and tris spheres as macropore template, PCL nanofibrous scaffolds with pores 300-800 μm, 1-10 μm and 100-1000 nm in diameter can be facilely produced. All scaffolds possess controlled nanofibrous morphology and porosity (90-98%). This scaffold may provide promising applications in tissue engineering and drug delivery.

KW - Biomaterials

KW - Hierarchical pores

KW - Nanofibrous scaffolds

KW - Phase separation

KW - Porous materials

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SN - 0167-577X

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SP - 62

EP - 65

JO - Materials Letters

JF - Materials Letters

ER -

Facilely fabricating PCL nanofibrous scaffolds with hierarchical pore structure for tissue engineering

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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