Facilely fabricating PCL nanofibrous scaffolds with hierarchical pore structure for tissue engineering

Yuzhang Du; Xiaofeng Chen; Young Hag Koh; Bo Lei

doi:10.1016/j.matlet.2014.02.031

Facilely fabricating PCL nanofibrous scaffolds with hierarchical pore structure for tissue engineering

Yuzhang Du, Xiaofeng Chen, Young Hag Koh, Bo Lei

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Highly hierarchical pore structure (macro-micro-nano) for biomimetic nanofibrous scaffolds could efficiently enhance cell infiltration and tissue formation. However, it is difficult to prepare these structures by using traditional electrostatic spinning techniques. Here, we report a facile method to fabricate polycaprolactone (PCL) nanofibrous scaffolds with multi-scale pore structure by simple phase separation. By employing water-dioxane as solvents and tris spheres as macropore template, PCL nanofibrous scaffolds with pores 300-800 μm, 1-10 μm and 100-1000 nm in diameter can be facilely produced. All scaffolds possess controlled nanofibrous morphology and porosity (90-98%). This scaffold may provide promising applications in tissue engineering and drug delivery.

Original language	English
Pages (from-to)	62-65
Number of pages	4
Journal	Materials Letters
Volume	122
DOIs	https://doi.org/10.1016/j.matlet.2014.02.031
Publication status	Published - 2014 May 1

Bibliographical note

Funding Information:
We acknowledge the valuable comments of potential reviewers. This work was supported by the Scientific Research Starting Foundation from Xi’an Jiaotong University , the National Natural Science Foundation of China ( 51072055 ), and the National 973 Project of China ( 2011CB606204 ).

Keywords

Biomaterials
Hierarchical pores
Nanofibrous scaffolds
Phase separation
Porous materials

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

Access to Document

10.1016/j.matlet.2014.02.031

Cite this

@article{e03a97490400447b93b4b3684443e57b,

title = "Facilely fabricating PCL nanofibrous scaffolds with hierarchical pore structure for tissue engineering",

abstract = "Highly hierarchical pore structure (macro-micro-nano) for biomimetic nanofibrous scaffolds could efficiently enhance cell infiltration and tissue formation. However, it is difficult to prepare these structures by using traditional electrostatic spinning techniques. Here, we report a facile method to fabricate polycaprolactone (PCL) nanofibrous scaffolds with multi-scale pore structure by simple phase separation. By employing water-dioxane as solvents and tris spheres as macropore template, PCL nanofibrous scaffolds with pores 300-800 μm, 1-10 μm and 100-1000 nm in diameter can be facilely produced. All scaffolds possess controlled nanofibrous morphology and porosity (90-98%). This scaffold may provide promising applications in tissue engineering and drug delivery.",

keywords = "Biomaterials, Hierarchical pores, Nanofibrous scaffolds, Phase separation, Porous materials",

author = "Yuzhang Du and Xiaofeng Chen and {Hag Koh}, Young and Bo Lei",

note = "Funding Information: We acknowledge the valuable comments of potential reviewers. This work was supported by the Scientific Research Starting Foundation from Xi{\textquoteright}an Jiaotong University , the National Natural Science Foundation of China ( 51072055 ), and the National 973 Project of China ( 2011CB606204 ). ",

year = "2014",

month = may,

day = "1",

doi = "10.1016/j.matlet.2014.02.031",

language = "English",

volume = "122",

pages = "62--65",

journal = "Materials Letters",

issn = "0167-577X",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Facilely fabricating PCL nanofibrous scaffolds with hierarchical pore structure for tissue engineering

AU - Du, Yuzhang

AU - Chen, Xiaofeng

AU - Hag Koh, Young

AU - Lei, Bo

N1 - Funding Information: We acknowledge the valuable comments of potential reviewers. This work was supported by the Scientific Research Starting Foundation from Xi’an Jiaotong University , the National Natural Science Foundation of China ( 51072055 ), and the National 973 Project of China ( 2011CB606204 ).

PY - 2014/5/1

Y1 - 2014/5/1

N2 - Highly hierarchical pore structure (macro-micro-nano) for biomimetic nanofibrous scaffolds could efficiently enhance cell infiltration and tissue formation. However, it is difficult to prepare these structures by using traditional electrostatic spinning techniques. Here, we report a facile method to fabricate polycaprolactone (PCL) nanofibrous scaffolds with multi-scale pore structure by simple phase separation. By employing water-dioxane as solvents and tris spheres as macropore template, PCL nanofibrous scaffolds with pores 300-800 μm, 1-10 μm and 100-1000 nm in diameter can be facilely produced. All scaffolds possess controlled nanofibrous morphology and porosity (90-98%). This scaffold may provide promising applications in tissue engineering and drug delivery.

AB - Highly hierarchical pore structure (macro-micro-nano) for biomimetic nanofibrous scaffolds could efficiently enhance cell infiltration and tissue formation. However, it is difficult to prepare these structures by using traditional electrostatic spinning techniques. Here, we report a facile method to fabricate polycaprolactone (PCL) nanofibrous scaffolds with multi-scale pore structure by simple phase separation. By employing water-dioxane as solvents and tris spheres as macropore template, PCL nanofibrous scaffolds with pores 300-800 μm, 1-10 μm and 100-1000 nm in diameter can be facilely produced. All scaffolds possess controlled nanofibrous morphology and porosity (90-98%). This scaffold may provide promising applications in tissue engineering and drug delivery.

KW - Biomaterials

KW - Hierarchical pores

KW - Nanofibrous scaffolds

KW - Phase separation

KW - Porous materials

UR - http://www.scopus.com/inward/record.url?scp=84894683292&partnerID=8YFLogxK

U2 - 10.1016/j.matlet.2014.02.031

DO - 10.1016/j.matlet.2014.02.031

M3 - Article

AN - SCOPUS:84894683292

SN - 0167-577X

VL - 122

SP - 62

EP - 65

JO - Materials Letters

JF - Materials Letters

ER -

Facilely fabricating PCL nanofibrous scaffolds with hierarchical pore structure for tissue engineering

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this