Facilely fabricating PCL nanofibrous scaffolds with hierarchical pore structure for tissue engineering

Yuzhang Du, Xiaofeng Chen, Young Hag Koh, Bo Lei

    Research output: Contribution to journalArticlepeer-review

    29 Citations (Scopus)

    Abstract

    Highly hierarchical pore structure (macro-micro-nano) for biomimetic nanofibrous scaffolds could efficiently enhance cell infiltration and tissue formation. However, it is difficult to prepare these structures by using traditional electrostatic spinning techniques. Here, we report a facile method to fabricate polycaprolactone (PCL) nanofibrous scaffolds with multi-scale pore structure by simple phase separation. By employing water-dioxane as solvents and tris spheres as macropore template, PCL nanofibrous scaffolds with pores 300-800 μm, 1-10 μm and 100-1000 nm in diameter can be facilely produced. All scaffolds possess controlled nanofibrous morphology and porosity (90-98%). This scaffold may provide promising applications in tissue engineering and drug delivery.

    Original languageEnglish
    Pages (from-to)62-65
    Number of pages4
    JournalMaterials Letters
    Volume122
    DOIs
    Publication statusPublished - 2014 May 1

    Bibliographical note

    Funding Information:
    We acknowledge the valuable comments of potential reviewers. This work was supported by the Scientific Research Starting Foundation from Xi’an Jiaotong University , the National Natural Science Foundation of China ( 51072055 ), and the National 973 Project of China ( 2011CB606204 ).

    Keywords

    • Biomaterials
    • Hierarchical pores
    • Nanofibrous scaffolds
    • Phase separation
    • Porous materials

    ASJC Scopus subject areas

    • General Materials Science
    • Condensed Matter Physics
    • Mechanics of Materials
    • Mechanical Engineering

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