Facilitated intracellular delivery of peptide-guided nanoparticles in tumor tissues

Jong Ho Kim; Sang Mun Bae; Moon Hee Na; Hyeri Shin; Yu Jin Yang; Kyung Hyun Min; Ki Young Choi; Kwangmeyung Kim; Rang Woon Park; Ick Chan Kwon; Byung Heon Lee; Allan S. Hoffman; In San Kim

doi:10.1016/j.jconrel.2011.09.070

Facilitated intracellular delivery of peptide-guided nanoparticles in tumor tissues

Jong Ho Kim
, Sang Mun Bae
, Moon Hee Na
, Hyeri Shin
, Yu Jin Yang
, Kyung Hyun Min
, Ki Young Choi
, Kwangmeyung Kim
, Rang Woon Park
, Ick Chan Kwon
, Byung Heon Lee
, Allan S. Hoffman
, In San Kim^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Macromolecular nanoparticles can extravasate and accumulate within tumor tissues via the passive targeting system, reflecting enhanced permeability and the retention effect. However, the unsatisfactory tumor therapeutic efficacy of the passive-targeting system, attributable to the retention of extravasated nanoparticles in the vicinity of tumor vessels, argues that a new system that facilitates intracellular delivery of nanoparticles within tumors is needed. Here, we developed hydrophobically modified glycol chitosan (HGC) nanoparticles conjugated with interleukin-4 receptor (IL-4R) binding peptides, termed I4R, and tested them in mice bearing IL-4R-positive tumors. These HGC-I4R nanoparticles exhibited enhanced IL-4R-dependent cellular uptake in tumors compared to nonconjugated nanoparticles, leading to better therapeutic and imaging efficacy. We conclude that I4R facilitates and enhances cellular uptake of nanoparticles in tumor tissues. This study suggests that the intracelluar uptake of nanoparticles in tumors is an essential factor to consider in designing nanoparticles for tumor-targeted drug delivery and imaging.

Original language	English
Pages (from-to)	493-499
Number of pages	7
Journal	Journal of Controlled Release
Volume	157
Issue number	3
DOIs	https://doi.org/10.1016/j.jconrel.2011.09.070
Publication status	Published - 2012 Feb 10

Bibliographical note

Funding Information:
This research was supported by the WCU (World Class University) program through the Korea Science and Engineering Foundation ( R33-2008-000-10054-0 ), the National Research foundation of Korea (NRF) grant funded by the Korea government (MEST) ( 2010-0029206 , 2011-001043 0), and the Converging Research Center Program through the Ministry of Education, Science and Technology ( 2010K001054 ).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer imaging
Cancer therapy
Homing peptide
Nanoparticles
Tumor targeting

ASJC Scopus subject areas

Pharmaceutical Science

Access to Document

10.1016/j.jconrel.2011.09.070

Cite this

@article{d67fbc7c623d47daba262a7187582253,

title = "Facilitated intracellular delivery of peptide-guided nanoparticles in tumor tissues",

abstract = "Macromolecular nanoparticles can extravasate and accumulate within tumor tissues via the passive targeting system, reflecting enhanced permeability and the retention effect. However, the unsatisfactory tumor therapeutic efficacy of the passive-targeting system, attributable to the retention of extravasated nanoparticles in the vicinity of tumor vessels, argues that a new system that facilitates intracellular delivery of nanoparticles within tumors is needed. Here, we developed hydrophobically modified glycol chitosan (HGC) nanoparticles conjugated with interleukin-4 receptor (IL-4R) binding peptides, termed I4R, and tested them in mice bearing IL-4R-positive tumors. These HGC-I4R nanoparticles exhibited enhanced IL-4R-dependent cellular uptake in tumors compared to nonconjugated nanoparticles, leading to better therapeutic and imaging efficacy. We conclude that I4R facilitates and enhances cellular uptake of nanoparticles in tumor tissues. This study suggests that the intracelluar uptake of nanoparticles in tumors is an essential factor to consider in designing nanoparticles for tumor-targeted drug delivery and imaging.",

keywords = "Cancer imaging, Cancer therapy, Homing peptide, Nanoparticles, Tumor targeting",

author = "Kim, \{Jong Ho\} and Bae, \{Sang Mun\} and Na, \{Moon Hee\} and Hyeri Shin and Yang, \{Yu Jin\} and Min, \{Kyung Hyun\} and Choi, \{Ki Young\} and Kwangmeyung Kim and Park, \{Rang Woon\} and Kwon, \{Ick Chan\} and Lee, \{Byung Heon\} and Hoffman, \{Allan S.\} and Kim, \{In San\}",

note = "Funding Information: This research was supported by the WCU (World Class University) program through the Korea Science and Engineering Foundation ( R33-2008-000-10054-0 ), the National Research foundation of Korea (NRF) grant funded by the Korea government (MEST) ( 2010-0029206 , 2011-001043 0), and the Converging Research Center Program through the Ministry of Education, Science and Technology ( 2010K001054 ). ",

year = "2012",

month = feb,

day = "10",

doi = "10.1016/j.jconrel.2011.09.070",

language = "English",

volume = "157",

pages = "493--499",

journal = "Journal of Controlled Release",

issn = "0168-3659",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - Facilitated intracellular delivery of peptide-guided nanoparticles in tumor tissues

AU - Kim, Jong Ho

AU - Bae, Sang Mun

AU - Na, Moon Hee

AU - Shin, Hyeri

AU - Yang, Yu Jin

AU - Min, Kyung Hyun

AU - Choi, Ki Young

AU - Kim, Kwangmeyung

AU - Park, Rang Woon

AU - Kwon, Ick Chan

AU - Lee, Byung Heon

AU - Hoffman, Allan S.

AU - Kim, In San

N1 - Funding Information: This research was supported by the WCU (World Class University) program through the Korea Science and Engineering Foundation ( R33-2008-000-10054-0 ), the National Research foundation of Korea (NRF) grant funded by the Korea government (MEST) ( 2010-0029206 , 2011-001043 0), and the Converging Research Center Program through the Ministry of Education, Science and Technology ( 2010K001054 ).

PY - 2012/2/10

Y1 - 2012/2/10

N2 - Macromolecular nanoparticles can extravasate and accumulate within tumor tissues via the passive targeting system, reflecting enhanced permeability and the retention effect. However, the unsatisfactory tumor therapeutic efficacy of the passive-targeting system, attributable to the retention of extravasated nanoparticles in the vicinity of tumor vessels, argues that a new system that facilitates intracellular delivery of nanoparticles within tumors is needed. Here, we developed hydrophobically modified glycol chitosan (HGC) nanoparticles conjugated with interleukin-4 receptor (IL-4R) binding peptides, termed I4R, and tested them in mice bearing IL-4R-positive tumors. These HGC-I4R nanoparticles exhibited enhanced IL-4R-dependent cellular uptake in tumors compared to nonconjugated nanoparticles, leading to better therapeutic and imaging efficacy. We conclude that I4R facilitates and enhances cellular uptake of nanoparticles in tumor tissues. This study suggests that the intracelluar uptake of nanoparticles in tumors is an essential factor to consider in designing nanoparticles for tumor-targeted drug delivery and imaging.

AB - Macromolecular nanoparticles can extravasate and accumulate within tumor tissues via the passive targeting system, reflecting enhanced permeability and the retention effect. However, the unsatisfactory tumor therapeutic efficacy of the passive-targeting system, attributable to the retention of extravasated nanoparticles in the vicinity of tumor vessels, argues that a new system that facilitates intracellular delivery of nanoparticles within tumors is needed. Here, we developed hydrophobically modified glycol chitosan (HGC) nanoparticles conjugated with interleukin-4 receptor (IL-4R) binding peptides, termed I4R, and tested them in mice bearing IL-4R-positive tumors. These HGC-I4R nanoparticles exhibited enhanced IL-4R-dependent cellular uptake in tumors compared to nonconjugated nanoparticles, leading to better therapeutic and imaging efficacy. We conclude that I4R facilitates and enhances cellular uptake of nanoparticles in tumor tissues. This study suggests that the intracelluar uptake of nanoparticles in tumors is an essential factor to consider in designing nanoparticles for tumor-targeted drug delivery and imaging.

KW - Cancer imaging

KW - Cancer therapy

KW - Homing peptide

KW - Nanoparticles

KW - Tumor targeting

UR - https://www.scopus.com/pages/publications/84857374141

U2 - 10.1016/j.jconrel.2011.09.070

DO - 10.1016/j.jconrel.2011.09.070

M3 - Article

C2 - 21945679

AN - SCOPUS:84857374141

SN - 0168-3659

VL - 157

SP - 493

EP - 499

JO - Journal of Controlled Release

JF - Journal of Controlled Release

IS - 3

ER -

Facilitated intracellular delivery of peptide-guided nanoparticles in tumor tissues

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this