Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea

Y. K. Kim, S. H. Kim, S. H. Choi, Y. H. Ko, L. Kim, M. S. Lee, K. Y. Suh, D. I. Kwak, K. J. Song, Y. J. Lee, R. Yanagihara, J. W. Song

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)

    Abstract

    RNA, extracted from peripheral blood mononuclear cells (PBMC) obtained from 81 Korean psychiatric patients (39 with schizophrenia, 33 with bipolar affective disorders and nine with major depression), was analyzed for a 391-nucleotide, highly conserved region of the p24 protein encoding ORF II of Borna disease virus (BDV), using nested reverse transcription-polymerase drain reaction (RT-PCR). BDV genomic RNA was not detected in PBMC from any of the 81 Korean psychiatric patients. These data do not support an etiologic association between BDV infection and neuropsychiatric disorders in humans.

    Original languageEnglish
    Pages (from-to)196-199
    Number of pages4
    JournalJournal of NeuroVirology
    Volume5
    Issue number2
    DOIs
    Publication statusPublished - 1999

    Bibliographical note

    Funding Information:
    The authors are grateful for the support of the NSF through Grant No. CTS9520153699 and the support of the Eastman Chemical Company.

    Keywords

    • Borna disease virus
    • PBMC
    • Psychiatric disorders
    • RT-PCR

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology
    • Cellular and Molecular Neuroscience
    • Virology

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