RNA, extracted from peripheral blood mononuclear cells (PBMC) obtained from 81 Korean psychiatric patients (39 with schizophrenia, 33 with bipolar affective disorders and nine with major depression), was analyzed for a 391-nucleotide, highly conserved region of the p24 protein encoding ORF II of Borna disease virus (BDV), using nested reverse transcription-polymerase drain reaction (RT-PCR). BDV genomic RNA was not detected in PBMC from any of the 81 Korean psychiatric patients. These data do not support an etiologic association between BDV infection and neuropsychiatric disorders in humans.
Bibliographical noteFunding Information:
The authors are grateful for the support of the NSF through Grant No. CTS9520153699 and the support of the Eastman Chemical Company.
- Borna disease virus
- Psychiatric disorders
ASJC Scopus subject areas
- Clinical Neurology
- Cellular and Molecular Neuroscience