Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea

Y. K. Kim; S. H. Kim; S. H. Choi; Y. H. Ko; L. Kim; M. S. Lee; K. Y. Suh; D. I. Kwak; K. J. Song; Y. J. Lee; R. Yanagihara; J. W. Song

doi:10.3109/13550289909022002

Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea

Y. K. Kim, S. H. Kim, S. H. Choi, Y. H. Ko, L. Kim, M. S. Lee, K. Y. Suh, D. I. Kwak, K. J. Song, Y. J. Lee, R. Yanagihara, J. W. Song

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26 Citations (Scopus)

Abstract

RNA, extracted from peripheral blood mononuclear cells (PBMC) obtained from 81 Korean psychiatric patients (39 with schizophrenia, 33 with bipolar affective disorders and nine with major depression), was analyzed for a 391-nucleotide, highly conserved region of the p24 protein encoding ORF II of Borna disease virus (BDV), using nested reverse transcription-polymerase drain reaction (RT-PCR). BDV genomic RNA was not detected in PBMC from any of the 81 Korean psychiatric patients. These data do not support an etiologic association between BDV infection and neuropsychiatric disorders in humans.

Original language	English
Pages (from-to)	196-199
Number of pages	4
Journal	Journal of NeuroVirology
Volume	5
Issue number	2
DOIs	https://doi.org/10.3109/13550289909022002
Publication status	Published - 1999

Bibliographical note

Funding Information:
The authors are grateful for the support of the NSF through Grant No. CTS9520153699 and the support of the Eastman Chemical Company.

Keywords

Borna disease virus
PBMC
Psychiatric disorders
RT-PCR

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cellular and Molecular Neuroscience
Virology

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10.3109/13550289909022002

Cite this

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title = "Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea",

abstract = "RNA, extracted from peripheral blood mononuclear cells (PBMC) obtained from 81 Korean psychiatric patients (39 with schizophrenia, 33 with bipolar affective disorders and nine with major depression), was analyzed for a 391-nucleotide, highly conserved region of the p24 protein encoding ORF II of Borna disease virus (BDV), using nested reverse transcription-polymerase drain reaction (RT-PCR). BDV genomic RNA was not detected in PBMC from any of the 81 Korean psychiatric patients. These data do not support an etiologic association between BDV infection and neuropsychiatric disorders in humans.",

keywords = "Borna disease virus, PBMC, Psychiatric disorders, RT-PCR",

author = "Kim, {Y. K.} and Kim, {S. H.} and Choi, {S. H.} and Ko, {Y. H.} and L. Kim and Lee, {M. S.} and Suh, {K. Y.} and Kwak, {D. I.} and Song, {K. J.} and Lee, {Y. J.} and R. Yanagihara and Song, {J. W.}",

note = "Funding Information: The authors are grateful for the support of the NSF through Grant No. CTS9520153699 and the support of the Eastman Chemical Company. ",

year = "1999",

doi = "10.3109/13550289909022002",

language = "English",

volume = "5",

pages = "196--199",

journal = "Journal of NeuroVirology",

issn = "1355-0284",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "2",

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TY - JOUR

T1 - Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea

AU - Kim, Y. K.

AU - Kim, S. H.

AU - Choi, S. H.

AU - Ko, Y. H.

AU - Kim, L.

AU - Lee, M. S.

AU - Suh, K. Y.

AU - Kwak, D. I.

AU - Song, K. J.

AU - Lee, Y. J.

AU - Yanagihara, R.

AU - Song, J. W.

N1 - Funding Information: The authors are grateful for the support of the NSF through Grant No. CTS9520153699 and the support of the Eastman Chemical Company.

PY - 1999

Y1 - 1999

N2 - RNA, extracted from peripheral blood mononuclear cells (PBMC) obtained from 81 Korean psychiatric patients (39 with schizophrenia, 33 with bipolar affective disorders and nine with major depression), was analyzed for a 391-nucleotide, highly conserved region of the p24 protein encoding ORF II of Borna disease virus (BDV), using nested reverse transcription-polymerase drain reaction (RT-PCR). BDV genomic RNA was not detected in PBMC from any of the 81 Korean psychiatric patients. These data do not support an etiologic association between BDV infection and neuropsychiatric disorders in humans.

AB - RNA, extracted from peripheral blood mononuclear cells (PBMC) obtained from 81 Korean psychiatric patients (39 with schizophrenia, 33 with bipolar affective disorders and nine with major depression), was analyzed for a 391-nucleotide, highly conserved region of the p24 protein encoding ORF II of Borna disease virus (BDV), using nested reverse transcription-polymerase drain reaction (RT-PCR). BDV genomic RNA was not detected in PBMC from any of the 81 Korean psychiatric patients. These data do not support an etiologic association between BDV infection and neuropsychiatric disorders in humans.

KW - Borna disease virus

KW - PBMC

KW - Psychiatric disorders

KW - RT-PCR

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U2 - 10.3109/13550289909022002

DO - 10.3109/13550289909022002

M3 - Article

C2 - 10321984

AN - SCOPUS:0032893353

SN - 1355-0284

VL - 5

SP - 196

EP - 199

JO - Journal of NeuroVirology

JF - Journal of NeuroVirology

IS - 2

ER -

Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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