Family History and Risk of Recurrent Stroke

Jong Won Chung, Beom Joon Kim, Moon Ku Han, Kyusik Kang, Jong Moo Park, Sang Soon Park, Tai Hwan Park, Yong Jin Cho, Keun Sik Hong, Kyung Bok Lee, Jae Guk Kim, Youngchai Ko, Soojoo Lee, Hyun Wook Nah, Dae Hyun Kim, Jae Kwan Cha, Mi Sun Oh, Kyung Ho Yu, Byung Chul Lee, Myung Suk JangJi Sung Lee, Juneyoung Lee, Hee Joon Bae

    Research output: Contribution to journalArticlepeer-review

    22 Citations (Scopus)


    Background and Purpose - The association between family history of stroke and stroke recurrence remains unclear. Methods - Using a web-based multicenter stroke registry database, information on history of stroke in first-degree relatives was collected prospectively for acute ischemic stroke patients who were hospitalized within 7 days of onset. The collected information was categorized as follows: type of the affected relative(s) with stroke (paternal, maternal, sibling, or 2 or more) and age of the relative's stroke onset (<50, 50-59, 60-69, and ≥70 years). Stroke recurrence was captured prospectively using a predetermined protocol. Subgroup analyses were performed according to the patient's age at the index stroke. Results - Among 7642 patients, 937 (12.3%) had a history of stroke in their first-degree relatives and 475 (6.2%: 201 within and 274 after 3 weeks from index stroke) experienced stroke recurrence (median follow-up, 365 days). In multivariable Cox proportional hazard models, overall family history was not associated with stroke recurrence (hazard ratio, 1.08; 95% confidence interval, 0.81-1.43). However, the details of their family histories, including relative's age at stroke onset (<50 years: hazard ratio, 2.14; 95% confidence interval, 1.004-4.54) and stroke history in a sibling (hazard ratio, 1.67; 95% confidence interval, 1.09-2.58), were independently associated with stroke recurrence after adjusting for potential confounders. The associations appeared to be stronger in young adults with stroke (age, <55 years) than in older stroke patients. Conclusions - This study suggests that elevated risks of recurrent stroke are associated with having relatives with early-onset stroke and siblings with stroke histories, implying that additional precautions may be needed in such populations.

    Original languageEnglish
    Pages (from-to)1990-1996
    Number of pages7
    Issue number8
    Publication statusPublished - 2016 Aug 1

    Bibliographical note

    Funding Information:
    Sources of Funding This study was supported by a grant from the Korea Healthcare Technology Research and Development Project, Ministry of Health and Welfare, Republic of Korea (HI10C2020).

    Publisher Copyright:
    © 2016 American Heart Association, Inc.


    • ischemia
    • prognosis
    • proportional hazard models
    • risk assessment
    • stroke

    ASJC Scopus subject areas

    • Clinical Neurology
    • Cardiology and Cardiovascular Medicine
    • Advanced and Specialised Nursing


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