Fbxw7β is an inducing mediator of dexamethasone-induced skeletal muscle atrophy in vivo with the axis of Fbxw7β-myogenin–atrogenes

Kyungshin Shin; Young Gyu Ko; Jaemin Jeong; Heechung Kwon

doi:10.1007/s11033-018-4185-9

Fbxw7β is an inducing mediator of dexamethasone-induced skeletal muscle atrophy in vivo with the axis of Fbxw7β-myogenin–atrogenes

Kyungshin Shin, Young Gyu Ko, Jaemin Jeong, Heechung Kwon

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Muscle atrophy is induced by several pathways, e.g., it can be attributed to inherited cachectic symptoms, genetic disorders, sarcopenia, or chronic side effects of treatments. However, the underlying regulatory mechanisms that contribute to muscle atrophy have not been fully elucidated. In this study, we evaluated the role of Fbxw7β, an ubiquitin E3 ligase, in a dexamethasone-induced muscle atrophy model. In this model, endogenous Fbxw7β was up-regulated; furthermore, the Fbxw7β-myogenin–atrogene axis was upregulated, supporting our previous results linking Fbxw7β to muscle atrophy in vitro. Also, muscle atrophy was associated with the Fbxw7β-myogenin–atrogene axis and the down-regulation of Dach2, a repressor of myogenin. Taken together, these results suggest that the ubiquitin E3 ligase Fbxw7β and the Fbxw7β-myogenin–atrogene axis have important roles in a dexamethasone-induced muscle atrophy model in vivo and in vitro. Additionally, the Fbxw7β-Dach2-myogenin–atrogene axis is a potential mechanism underlying muscle atrophy in cases of abnormal Fbxw7β expression-induced muscle atrophy or myogenic degenerative disease.

Original language	English
Pages (from-to)	625-631
Number of pages	7
Journal	Molecular biology reports
Volume	45
Issue number	4
DOIs	https://doi.org/10.1007/s11033-018-4185-9
Publication status	Published - 2018 Aug 1

Bibliographical note

Funding Information:
Acknowledgements This study was supported by a grant of the Korea Institute of Radiological and Medical Sciences (KIRAMS), funded by Ministry of Science and ICT (MSIT), Republic of Korea (1711042677; 1711045548; 1711045553; 1711045555/50534-2017) and by the Radiation Medicine Research Program through the National Research Foundation of Korea (NRF) (NRF-2017M2A2A7A01070970/50043-2017), funded by the Ministry of Science and ICT (MSIT), Republic of Korea.

Publisher Copyright:
© 2018, Springer Science+Business Media B.V., part of Springer Nature.

Keywords

Atrogenes
Dach2
Dexamethasone
Fbxw7β
Myogenin
Skeletal muscle atrophy

ASJC Scopus subject areas

Molecular Biology
Genetics

Access to Document

10.1007/s11033-018-4185-9

Cite this

@article{51e591735c564b87b2f5882fb20727b3,

title = "Fbxw7β is an inducing mediator of dexamethasone-induced skeletal muscle atrophy in vivo with the axis of Fbxw7β-myogenin–atrogenes",

abstract = "Muscle atrophy is induced by several pathways, e.g., it can be attributed to inherited cachectic symptoms, genetic disorders, sarcopenia, or chronic side effects of treatments. However, the underlying regulatory mechanisms that contribute to muscle atrophy have not been fully elucidated. In this study, we evaluated the role of Fbxw7β, an ubiquitin E3 ligase, in a dexamethasone-induced muscle atrophy model. In this model, endogenous Fbxw7β was up-regulated; furthermore, the Fbxw7β-myogenin–atrogene axis was upregulated, supporting our previous results linking Fbxw7β to muscle atrophy in vitro. Also, muscle atrophy was associated with the Fbxw7β-myogenin–atrogene axis and the down-regulation of Dach2, a repressor of myogenin. Taken together, these results suggest that the ubiquitin E3 ligase Fbxw7β and the Fbxw7β-myogenin–atrogene axis have important roles in a dexamethasone-induced muscle atrophy model in vivo and in vitro. Additionally, the Fbxw7β-Dach2-myogenin–atrogene axis is a potential mechanism underlying muscle atrophy in cases of abnormal Fbxw7β expression-induced muscle atrophy or myogenic degenerative disease.",

keywords = "Atrogenes, Dach2, Dexamethasone, Fbxw7β, Myogenin, Skeletal muscle atrophy",

author = "Kyungshin Shin and Ko, {Young Gyu} and Jaemin Jeong and Heechung Kwon",

note = "Funding Information: Acknowledgements This study was supported by a grant of the Korea Institute of Radiological and Medical Sciences (KIRAMS), funded by Ministry of Science and ICT (MSIT), Republic of Korea (1711042677; 1711045548; 1711045553; 1711045555/50534-2017) and by the Radiation Medicine Research Program through the National Research Foundation of Korea (NRF) (NRF-2017M2A2A7A01070970/50043-2017), funded by the Ministry of Science and ICT (MSIT), Republic of Korea. Publisher Copyright: {\textcopyright} 2018, Springer Science+Business Media B.V., part of Springer Nature.",

year = "2018",

month = aug,

day = "1",

doi = "10.1007/s11033-018-4185-9",

language = "English",

volume = "45",

pages = "625--631",

journal = "Molecular biology reports",

issn = "0301-4851",

publisher = "Springer Netherlands",

number = "4",

}

TY - JOUR

T1 - Fbxw7β is an inducing mediator of dexamethasone-induced skeletal muscle atrophy in vivo with the axis of Fbxw7β-myogenin–atrogenes

AU - Shin, Kyungshin

AU - Ko, Young Gyu

AU - Jeong, Jaemin

AU - Kwon, Heechung

N1 - Funding Information: Acknowledgements This study was supported by a grant of the Korea Institute of Radiological and Medical Sciences (KIRAMS), funded by Ministry of Science and ICT (MSIT), Republic of Korea (1711042677; 1711045548; 1711045553; 1711045555/50534-2017) and by the Radiation Medicine Research Program through the National Research Foundation of Korea (NRF) (NRF-2017M2A2A7A01070970/50043-2017), funded by the Ministry of Science and ICT (MSIT), Republic of Korea. Publisher Copyright: © 2018, Springer Science+Business Media B.V., part of Springer Nature.

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Muscle atrophy is induced by several pathways, e.g., it can be attributed to inherited cachectic symptoms, genetic disorders, sarcopenia, or chronic side effects of treatments. However, the underlying regulatory mechanisms that contribute to muscle atrophy have not been fully elucidated. In this study, we evaluated the role of Fbxw7β, an ubiquitin E3 ligase, in a dexamethasone-induced muscle atrophy model. In this model, endogenous Fbxw7β was up-regulated; furthermore, the Fbxw7β-myogenin–atrogene axis was upregulated, supporting our previous results linking Fbxw7β to muscle atrophy in vitro. Also, muscle atrophy was associated with the Fbxw7β-myogenin–atrogene axis and the down-regulation of Dach2, a repressor of myogenin. Taken together, these results suggest that the ubiquitin E3 ligase Fbxw7β and the Fbxw7β-myogenin–atrogene axis have important roles in a dexamethasone-induced muscle atrophy model in vivo and in vitro. Additionally, the Fbxw7β-Dach2-myogenin–atrogene axis is a potential mechanism underlying muscle atrophy in cases of abnormal Fbxw7β expression-induced muscle atrophy or myogenic degenerative disease.

AB - Muscle atrophy is induced by several pathways, e.g., it can be attributed to inherited cachectic symptoms, genetic disorders, sarcopenia, or chronic side effects of treatments. However, the underlying regulatory mechanisms that contribute to muscle atrophy have not been fully elucidated. In this study, we evaluated the role of Fbxw7β, an ubiquitin E3 ligase, in a dexamethasone-induced muscle atrophy model. In this model, endogenous Fbxw7β was up-regulated; furthermore, the Fbxw7β-myogenin–atrogene axis was upregulated, supporting our previous results linking Fbxw7β to muscle atrophy in vitro. Also, muscle atrophy was associated with the Fbxw7β-myogenin–atrogene axis and the down-regulation of Dach2, a repressor of myogenin. Taken together, these results suggest that the ubiquitin E3 ligase Fbxw7β and the Fbxw7β-myogenin–atrogene axis have important roles in a dexamethasone-induced muscle atrophy model in vivo and in vitro. Additionally, the Fbxw7β-Dach2-myogenin–atrogene axis is a potential mechanism underlying muscle atrophy in cases of abnormal Fbxw7β expression-induced muscle atrophy or myogenic degenerative disease.

KW - Atrogenes

KW - Dach2

KW - Dexamethasone

KW - Fbxw7β

KW - Myogenin

KW - Skeletal muscle atrophy

UR - http://www.scopus.com/inward/record.url?scp=85045633864&partnerID=8YFLogxK

U2 - 10.1007/s11033-018-4185-9

DO - 10.1007/s11033-018-4185-9

M3 - Article

C2 - 29671242

AN - SCOPUS:85045633864

SN - 0301-4851

VL - 45

SP - 625

EP - 631

JO - Molecular biology reports

JF - Molecular biology reports

IS - 4

ER -

Fbxw7β is an inducing mediator of dexamethasone-induced skeletal muscle atrophy in vivo with the axis of Fbxw7β-myogenin–atrogenes

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this