Abstract
Purpose: The aim of this study was to evaluate the feasibility of FP-CIT PET template-based quantitative analysis on F-18 FP-CIT PET in patients with de novo Parkinson's disease (PD), compared with MR-based and manual methods. We also assessed the correlation of quantitative parameters of those methods with clinical severity of the disease. Methods: Forty patients with de novo PD underwent both MRI and F-18 FP-CIT PET. Images were spatially normalized to a standardized PET template. Mean counts of 4 ROIs: putamen, caudate, occipital cortex and cerebellum, were obtained using the quantification program, Korean Statistical Probabilistic Anatomical Map (KSPAM). Putamen-to-caudate ratio (PCR), asymmetry index (ASI), specific-to-nonspecific ratios with two different references: to occipital cortex (SOR) and cerebellum (SCR) were compared. Parameters were also calculated from manually drawn ROI method and MR-coregistrated method. Results: All quantitative parameters showed significant correlations across the three different methods, especially between the PET-based and manual methods. Among them, PET-based SOR and SCR values showed an excellent correlation and concordance with those of manual method. In relationship with clinical severity, only ASI achieved significantly inverse correlations with H&Y stage and UPDRS motor score. There was no significant difference between the quantitative parameters of both occipital cortex and cerebellum in all three methods, which implied that quantitation using PET-based method could be reproducible regardless of the reference region. Conclusions: Quantitative parameters using FP-CIT PET template-based method correlated well with those using laborious manual method with excellent concordance. Moreover, PET-based quantitation was less influenced by the reference region than MR-based method. It suggests that PET-based method can provide objective and quantitative parameters quickly and easily as a feasible analysis in place of conventional method.
Original language | English |
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Pages (from-to) | 73-80 |
Number of pages | 8 |
Journal | Nuclear Medicine and Molecular Imaging |
Volume | 47 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2013 Jun |
Bibliographical note
Funding Information:This study was partly supported by Korea University Research Special Grants (2011-K1131781, 2011-K1132941). We had no conflicts of interest relevant to this study.
Keywords
- Dopamine transporter (DAT)
- F-18 FP-CIT PET
- Korean statistical probabilistic anatomical map (KSPAM)
- Parkinson's disease
- Template-based quantitative analysis
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging