Fermented mixed grain ameliorates chronic stress-induced depression-like behavior and memory deficit

Jae Gwang Song, Bomi Lee, Do Eon Kim, Bong Kyeong Seo, Nam Su Oh, Sae Hun Kim, Hyung Wook Kim

Research output: Contribution to journalArticlepeer-review


Fermented mixed grain (FG) has beneficial anti-cancer, antioxidant, and anti-inflammatory effects. In this study, we investigated the effects of FG on gut inflammation, brain dysfunction, and anxiety/depression-like behavior induced by unpredictable chronic mild stress (UCMS) in mice. Mice were administered mixed grain or FG for 3 weeks and were then exposed to UCMS for 4 weeks. FG administration ameliorated stress-induced anxiety/despair-like behavior. FG administration also prevented UCMS-induced memory impairment. Additionally, the mRNA levels of 5-HTR1A and IL-6 were restored to normal levels in the brains of FG-administered mice. FG administration also inhibited intestinal damage in stressed mice compared with that in the UCMS (without FG) group. These results suggest that FG can alleviate stress-induced intestinal damage, brain dysfunction, and cognitive impairment.

Original languageEnglish
Pages (from-to)969-979
Number of pages11
JournalFood Science and Biotechnology
Issue number4
Publication statusPublished - 2024 Mar

Bibliographical note

Publisher Copyright:
© The Korean Society of Food Science and Technology 2023.


  • Chronic mild stress
  • Depression-like behaviour
  • Fermented grain
  • Memory impairment

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology


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