Fermented mixed grain ameliorates chronic stress-induced depression-like behavior and memory deficit

Jae Gwang Song; Bomi Lee; Do Eon Kim; Bong Kyeong Seo; Nam Su Oh; Sae Hun Kim; Hyung Wook Kim

doi:10.1007/s10068-023-01387-x

Fermented mixed grain ameliorates chronic stress-induced depression-like behavior and memory deficit

Jae Gwang Song
, Bomi Lee
, Do Eon Kim
, Bong Kyeong Seo
, Nam Su Oh^*
, Sae Hun Kim^*
, Hyung Wook Kim^*

^*Corresponding author for this work

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Fermented mixed grain (FG) has beneficial anti-cancer, antioxidant, and anti-inflammatory effects. In this study, we investigated the effects of FG on gut inflammation, brain dysfunction, and anxiety/depression-like behavior induced by unpredictable chronic mild stress (UCMS) in mice. Mice were administered mixed grain or FG for 3 weeks and were then exposed to UCMS for 4 weeks. FG administration ameliorated stress-induced anxiety/despair-like behavior. FG administration also prevented UCMS-induced memory impairment. Additionally, the mRNA levels of 5-HTR1A and IL-6 were restored to normal levels in the brains of FG-administered mice. FG administration also inhibited intestinal damage in stressed mice compared with that in the UCMS (without FG) group. These results suggest that FG can alleviate stress-induced intestinal damage, brain dysfunction, and cognitive impairment.

Original language	English
Pages (from-to)	969-979
Number of pages	11
Journal	Food Science and Biotechnology
Volume	33
Issue number	4
DOIs	https://doi.org/10.1007/s10068-023-01387-x
Publication status	Published - 2024 Mar

Bibliographical note

Publisher Copyright:
© The Korean Society of Food Science and Technology 2023.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chronic mild stress
Depression-like behaviour
Fermented grain
Memory impairment

ASJC Scopus subject areas

Biotechnology
Food Science
Applied Microbiology and Biotechnology

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10.1007/s10068-023-01387-x

Cite this

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title = "Fermented mixed grain ameliorates chronic stress-induced depression-like behavior and memory deficit",

abstract = "Fermented mixed grain (FG) has beneficial anti-cancer, antioxidant, and anti-inflammatory effects. In this study, we investigated the effects of FG on gut inflammation, brain dysfunction, and anxiety/depression-like behavior induced by unpredictable chronic mild stress (UCMS) in mice. Mice were administered mixed grain or FG for 3 weeks and were then exposed to UCMS for 4 weeks. FG administration ameliorated stress-induced anxiety/despair-like behavior. FG administration also prevented UCMS-induced memory impairment. Additionally, the mRNA levels of 5-HTR1A and IL-6 were restored to normal levels in the brains of FG-administered mice. FG administration also inhibited intestinal damage in stressed mice compared with that in the UCMS (without FG) group. These results suggest that FG can alleviate stress-induced intestinal damage, brain dysfunction, and cognitive impairment.",

keywords = "Chronic mild stress, Depression-like behaviour, Fermented grain, Memory impairment",

author = "Song, \{Jae Gwang\} and Bomi Lee and Kim, \{Do Eon\} and Seo, \{Bong Kyeong\} and Oh, \{Nam Su\} and Kim, \{Sae Hun\} and Kim, \{Hyung Wook\}",

note = "Publisher Copyright: {\textcopyright} The Korean Society of Food Science and Technology 2023.",

year = "2024",

month = mar,

doi = "10.1007/s10068-023-01387-x",

language = "English",

volume = "33",

pages = "969--979",

journal = "Food Science and Biotechnology",

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publisher = "The Korean Society of Food Science and Technology",

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TY - JOUR

T1 - Fermented mixed grain ameliorates chronic stress-induced depression-like behavior and memory deficit

AU - Song, Jae Gwang

AU - Lee, Bomi

AU - Kim, Do Eon

AU - Seo, Bong Kyeong

AU - Oh, Nam Su

AU - Kim, Sae Hun

AU - Kim, Hyung Wook

PY - 2024/3

Y1 - 2024/3

N2 - Fermented mixed grain (FG) has beneficial anti-cancer, antioxidant, and anti-inflammatory effects. In this study, we investigated the effects of FG on gut inflammation, brain dysfunction, and anxiety/depression-like behavior induced by unpredictable chronic mild stress (UCMS) in mice. Mice were administered mixed grain or FG for 3 weeks and were then exposed to UCMS for 4 weeks. FG administration ameliorated stress-induced anxiety/despair-like behavior. FG administration also prevented UCMS-induced memory impairment. Additionally, the mRNA levels of 5-HTR1A and IL-6 were restored to normal levels in the brains of FG-administered mice. FG administration also inhibited intestinal damage in stressed mice compared with that in the UCMS (without FG) group. These results suggest that FG can alleviate stress-induced intestinal damage, brain dysfunction, and cognitive impairment.

AB - Fermented mixed grain (FG) has beneficial anti-cancer, antioxidant, and anti-inflammatory effects. In this study, we investigated the effects of FG on gut inflammation, brain dysfunction, and anxiety/depression-like behavior induced by unpredictable chronic mild stress (UCMS) in mice. Mice were administered mixed grain or FG for 3 weeks and were then exposed to UCMS for 4 weeks. FG administration ameliorated stress-induced anxiety/despair-like behavior. FG administration also prevented UCMS-induced memory impairment. Additionally, the mRNA levels of 5-HTR1A and IL-6 were restored to normal levels in the brains of FG-administered mice. FG administration also inhibited intestinal damage in stressed mice compared with that in the UCMS (without FG) group. These results suggest that FG can alleviate stress-induced intestinal damage, brain dysfunction, and cognitive impairment.

KW - Chronic mild stress

KW - Depression-like behaviour

KW - Fermented grain

KW - Memory impairment

UR - https://www.scopus.com/pages/publications/85165873976

U2 - 10.1007/s10068-023-01387-x

DO - 10.1007/s10068-023-01387-x

M3 - Article

AN - SCOPUS:85165873976

SN - 1226-7708

VL - 33

SP - 969

EP - 979

JO - Food Science and Biotechnology

JF - Food Science and Biotechnology

IS - 4

ER -

Fermented mixed grain ameliorates chronic stress-induced depression-like behavior and memory deficit

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this