Ferroptosis-related genes in neurodevelopment and central nervous system

Soo Whee Kim, Yujin Kim, Sung Eun Kim, Joon Yong An

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)

Abstract

Ferroptosis, first introduced as a new form of regulated cell death induced by erastin, is accompanied by the accumulation of iron and lipid peroxides, thus it can be inhibited either by iron chelators or by lipophilic antioxidants. In the past decade, multiple studies have introduced the potential importance of ferroptosis in many human diseases, including cancer and neurodegenerative diseases. In this review, we will discuss the genetic association of ferroptosis with neurological disorders and development of the central nervous system.

Original languageEnglish
Article number35
Pages (from-to)1-18
Number of pages18
JournalBiology
Volume10
Issue number1
DOIs
Publication statusPublished - 2021 Jan

Bibliographical note

Funding Information:
This work was supported by a Korea University Grant K2019171 (J.-Y.A.), the Korean NRF Grant 2019M3E5D3073568 (J.-Y.A.) and R2002661 (S.E.K.).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Brain development
  • CNS
  • Ferroptosis
  • Iron
  • Lipid peroxides
  • Neurological disorder

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Agricultural and Biological Sciences

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