Ferroptosis-related genes in neurodevelopment and central nervous system

Soo Whee Kim; Yujin Kim; Sung Eun Kim; Joon Yong An

doi:10.3390/biology10010035

Ferroptosis-related genes in neurodevelopment and central nervous system

Soo Whee Kim, Yujin Kim, Sung Eun Kim, Joon Yong An

Research output: Contribution to journal › Review article › peer-review

16 Citations (Scopus)

Abstract

Ferroptosis, first introduced as a new form of regulated cell death induced by erastin, is accompanied by the accumulation of iron and lipid peroxides, thus it can be inhibited either by iron chelators or by lipophilic antioxidants. In the past decade, multiple studies have introduced the potential importance of ferroptosis in many human diseases, including cancer and neurodegenerative diseases. In this review, we will discuss the genetic association of ferroptosis with neurological disorders and development of the central nervous system.

Original language	English
Article number	35
Pages (from-to)	1-18
Number of pages	18
Journal	Biology
Volume	10
Issue number	1
DOIs	https://doi.org/10.3390/biology10010035
Publication status	Published - 2021 Jan

Bibliographical note

Funding Information:
This work was supported by a Korea University Grant K2019171 (J.-Y.A.), the Korean NRF Grant 2019M3E5D3073568 (J.-Y.A.) and R2002661 (S.E.K.).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Brain development
CNS
Ferroptosis
Iron
Lipid peroxides
Neurological disorder

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Agricultural and Biological Sciences(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/biology10010035

Cite this

@article{28134b7423ca41a2858d8d5bebab72fa,

title = "Ferroptosis-related genes in neurodevelopment and central nervous system",

abstract = "Ferroptosis, first introduced as a new form of regulated cell death induced by erastin, is accompanied by the accumulation of iron and lipid peroxides, thus it can be inhibited either by iron chelators or by lipophilic antioxidants. In the past decade, multiple studies have introduced the potential importance of ferroptosis in many human diseases, including cancer and neurodegenerative diseases. In this review, we will discuss the genetic association of ferroptosis with neurological disorders and development of the central nervous system.",

keywords = "Brain development, CNS, Ferroptosis, Iron, Lipid peroxides, Neurological disorder",

author = "Kim, {Soo Whee} and Yujin Kim and Kim, {Sung Eun} and An, {Joon Yong}",

note = "Funding Information: This work was supported by a Korea University Grant K2019171 (J.-Y.A.), the Korean NRF Grant 2019M3E5D3073568 (J.-Y.A.) and R2002661 (S.E.K.). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = jan,

doi = "10.3390/biology10010035",

language = "English",

volume = "10",

pages = "1--18",

journal = "Biology",

issn = "2079-7737",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "1",

}

TY - JOUR

T1 - Ferroptosis-related genes in neurodevelopment and central nervous system

AU - Kim, Soo Whee

AU - Kim, Yujin

AU - Kim, Sung Eun

AU - An, Joon Yong

N1 - Funding Information: This work was supported by a Korea University Grant K2019171 (J.-Y.A.), the Korean NRF Grant 2019M3E5D3073568 (J.-Y.A.) and R2002661 (S.E.K.). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/1

Y1 - 2021/1

N2 - Ferroptosis, first introduced as a new form of regulated cell death induced by erastin, is accompanied by the accumulation of iron and lipid peroxides, thus it can be inhibited either by iron chelators or by lipophilic antioxidants. In the past decade, multiple studies have introduced the potential importance of ferroptosis in many human diseases, including cancer and neurodegenerative diseases. In this review, we will discuss the genetic association of ferroptosis with neurological disorders and development of the central nervous system.

AB - Ferroptosis, first introduced as a new form of regulated cell death induced by erastin, is accompanied by the accumulation of iron and lipid peroxides, thus it can be inhibited either by iron chelators or by lipophilic antioxidants. In the past decade, multiple studies have introduced the potential importance of ferroptosis in many human diseases, including cancer and neurodegenerative diseases. In this review, we will discuss the genetic association of ferroptosis with neurological disorders and development of the central nervous system.

KW - Brain development

KW - CNS

KW - Ferroptosis

KW - Iron

KW - Lipid peroxides

KW - Neurological disorder

UR - http://www.scopus.com/inward/record.url?scp=85099461376&partnerID=8YFLogxK

U2 - 10.3390/biology10010035

DO - 10.3390/biology10010035

M3 - Review article

AN - SCOPUS:85099461376

SN - 2079-7737

VL - 10

SP - 1

EP - 18

JO - Biology

JF - Biology

IS - 1

M1 - 35

ER -

Ferroptosis-related genes in neurodevelopment and central nervous system

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this