Ferroptosis, first introduced as a new form of regulated cell death induced by erastin, is accompanied by the accumulation of iron and lipid peroxides, thus it can be inhibited either by iron chelators or by lipophilic antioxidants. In the past decade, multiple studies have introduced the potential importance of ferroptosis in many human diseases, including cancer and neurodegenerative diseases. In this review, we will discuss the genetic association of ferroptosis with neurological disorders and development of the central nervous system.
Bibliographical noteFunding Information:
This work was supported by a Korea University Grant K2019171 (J.-Y.A.), the Korean NRF Grant 2019M3E5D3073568 (J.-Y.A.) and R2002661 (S.E.K.).
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
- Brain development
- Lipid peroxides
- Neurological disorder
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Agricultural and Biological Sciences(all)