Ferulic acid supplementation prevents trimethyltin-induced cognitive deficits in mice

Mi Jeong Kim; Soo Jung Choi; Seung Taik Lim; Hye Kyung Kim; Ho Jin Heo; Eun Ki Kim; Woo Jin Jun; Hong Yon Cho; Young Jun Kim; Dong Hoon Shin

doi:10.1271/bbb.60564

Ferulic acid supplementation prevents trimethyltin-induced cognitive deficits in mice

Mi Jeong Kim, Soo Jung Choi, Seung Taik Lim, Hye Kyung Kim, Ho Jin Heo, Eun Ki Kim, Woo Jin Jun, Hong Yon Cho, Young Jun Kim, Dong Hoon Shin

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

This study's objective was to clarify the ameliorative effects ferulic acid (4-hydroxy-3-methoxycinnamic acid) has against cognitive deficits and ChAT activation in trimethyltin (TMT) induced, memory injured mice following a 28-d ferulic acid treatment. After administering TMT for 3 d, each mouse performed Y-maze and passive avoidance tests to check immediate working memory performance and cognitive function. The results showed that ferulic acid administration attenuated TMT-induced memory injury and a decline in ChAT activity in the mice. This suggests that ferulic acid might be useful for preventing cognitive dysfunction as well as for boosting the activation of ChAT in dementia.

Original language	English
Pages (from-to)	1063-1068
Number of pages	6
Journal	Bioscience, Biotechnology and Biochemistry
Volume	71
Issue number	4
DOIs	https://doi.org/10.1271/bbb.60564
Publication status	Published - 2007

Bibliographical note

Funding Information:
This study was supported by a grant (code #20050401034615) from the BioGreen 21 Program, Rural Development Administration, Republic of Korea.

Keywords

Choline acetyltransferase
Cognitive function
Ferulic acid (4-hydroxy-3-methoxycinnamic acid)
Trimethyltin

ASJC Scopus subject areas

General Medicine

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10.1271/bbb.60564

Cite this

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title = "Ferulic acid supplementation prevents trimethyltin-induced cognitive deficits in mice",

abstract = "This study's objective was to clarify the ameliorative effects ferulic acid (4-hydroxy-3-methoxycinnamic acid) has against cognitive deficits and ChAT activation in trimethyltin (TMT) induced, memory injured mice following a 28-d ferulic acid treatment. After administering TMT for 3 d, each mouse performed Y-maze and passive avoidance tests to check immediate working memory performance and cognitive function. The results showed that ferulic acid administration attenuated TMT-induced memory injury and a decline in ChAT activity in the mice. This suggests that ferulic acid might be useful for preventing cognitive dysfunction as well as for boosting the activation of ChAT in dementia.",

keywords = "Choline acetyltransferase, Cognitive function, Ferulic acid (4-hydroxy-3-methoxycinnamic acid), Trimethyltin",

author = "Kim, {Mi Jeong} and Choi, {Soo Jung} and Lim, {Seung Taik} and Kim, {Hye Kyung} and Heo, {Ho Jin} and Kim, {Eun Ki} and Jun, {Woo Jin} and Cho, {Hong Yon} and Kim, {Young Jun} and Shin, {Dong Hoon}",

note = "Funding Information: This study was supported by a grant (code #20050401034615) from the BioGreen 21 Program, Rural Development Administration, Republic of Korea.",

year = "2007",

doi = "10.1271/bbb.60564",

language = "English",

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pages = "1063--1068",

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T1 - Ferulic acid supplementation prevents trimethyltin-induced cognitive deficits in mice

AU - Kim, Mi Jeong

AU - Choi, Soo Jung

AU - Lim, Seung Taik

AU - Kim, Hye Kyung

AU - Heo, Ho Jin

AU - Kim, Eun Ki

AU - Jun, Woo Jin

AU - Cho, Hong Yon

AU - Kim, Young Jun

AU - Shin, Dong Hoon

N1 - Funding Information: This study was supported by a grant (code #20050401034615) from the BioGreen 21 Program, Rural Development Administration, Republic of Korea.

PY - 2007

Y1 - 2007

N2 - This study's objective was to clarify the ameliorative effects ferulic acid (4-hydroxy-3-methoxycinnamic acid) has against cognitive deficits and ChAT activation in trimethyltin (TMT) induced, memory injured mice following a 28-d ferulic acid treatment. After administering TMT for 3 d, each mouse performed Y-maze and passive avoidance tests to check immediate working memory performance and cognitive function. The results showed that ferulic acid administration attenuated TMT-induced memory injury and a decline in ChAT activity in the mice. This suggests that ferulic acid might be useful for preventing cognitive dysfunction as well as for boosting the activation of ChAT in dementia.

AB - This study's objective was to clarify the ameliorative effects ferulic acid (4-hydroxy-3-methoxycinnamic acid) has against cognitive deficits and ChAT activation in trimethyltin (TMT) induced, memory injured mice following a 28-d ferulic acid treatment. After administering TMT for 3 d, each mouse performed Y-maze and passive avoidance tests to check immediate working memory performance and cognitive function. The results showed that ferulic acid administration attenuated TMT-induced memory injury and a decline in ChAT activity in the mice. This suggests that ferulic acid might be useful for preventing cognitive dysfunction as well as for boosting the activation of ChAT in dementia.

KW - Choline acetyltransferase

KW - Cognitive function

KW - Ferulic acid (4-hydroxy-3-methoxycinnamic acid)

KW - Trimethyltin

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SN - 0916-8451

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SP - 1063

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JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 4

ER -

Ferulic acid supplementation prevents trimethyltin-induced cognitive deficits in mice

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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