Five potential therapeutic agents as antidepressants: A brief review and future directions

Sheng Min Wang, Changsu Han, Soo Jung Lee, Ashwin A. Patkar, Prakash S. Masand, Chi Un Pae

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)


Despite the availability of numerous antidepressants, many patients with depression do not show adequate response. The therapeutic lag between drug administration and onset of clinical improvement observed with conventional antidepressants has led to a need for antidepressants with a novel mechanism of action. Recently, five such agents, including acetyl-L-carnitine, scopolamine, ω-3 polyunsaturated fatty acids, ketamine, and selective 5-HT7 serotonin receptor antagonists, have gained interest as potential antidepressants with enhanced symptom control, improved tolerability, and faster onset of action compared to conventional antidepressants. This review provides an update and critical examination of these five novel therapeutic agents as potential antidepressants.

Original languageEnglish
Pages (from-to)1015-1029
Number of pages15
JournalExpert Review of Neurotherapeutics
Issue number9
Publication statusPublished - 2015 Sept 2
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI12C0003). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Publisher Copyright:
© 2015 Informa UK, Ltd.


  • acetyl-L-carnitine
  • depression
  • ketamine
  • novel mechanism
  • scopolamine
  • selective 5-HT7 serotonin receptor antagonist
  • w-3 polyunsaturated fatty acids

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)


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