Flash synthesis of TAC-101 and its analogues from 1,3,5-tribromobenzene using integrated flow microreactor systems

Aiichiro Nagaki; Keita Imai; Heejin Kim; Jun Ichi Yoshida

doi:10.1039/c1ra00377a

Flash synthesis of TAC-101 and its analogues from 1,3,5-tribromobenzene using integrated flow microreactor systems

Aiichiro Nagaki, Keita Imai, Heejin Kim, Jun Ichi Yoshida

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Sequential introduction of three electrophiles into 1,3,5-tribromobenzene based on Br/Li exchange reaction was achieved using an integrated flow microreactor system consisting of six micromixers and six microtube reactors. This method enables flash synthesis of TAC-101 and its analogues within 13 s in good yields on a preparative scale.

Original language	English
Pages (from-to)	758-760
Number of pages	3
Journal	RSC Advances
Volume	1
Issue number	5
DOIs	https://doi.org/10.1039/c1ra00377a
Publication status	Published - 2011 Oct 7
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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10.1039/c1ra00377a

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abstract = "Sequential introduction of three electrophiles into 1,3,5-tribromobenzene based on Br/Li exchange reaction was achieved using an integrated flow microreactor system consisting of six micromixers and six microtube reactors. This method enables flash synthesis of TAC-101 and its analogues within 13 s in good yields on a preparative scale.",

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AU - Yoshida, Jun Ichi

PY - 2011/10/7

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AB - Sequential introduction of three electrophiles into 1,3,5-tribromobenzene based on Br/Li exchange reaction was achieved using an integrated flow microreactor system consisting of six micromixers and six microtube reactors. This method enables flash synthesis of TAC-101 and its analogues within 13 s in good yields on a preparative scale.

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Flash synthesis of TAC-101 and its analogues from 1,3,5-tribromobenzene using integrated flow microreactor systems

Abstract

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