Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics

Gunchul Shin; Adrian M. Gomez; Ream Al-Hasani; Yu Ra Jeong; Jeonghyun Kim; Zhaoqian Xie; Anthony Banks; Seung Min Lee; Sang Youn Han; Chul Jong Yoo; Jong Lam Lee; Seung Hee Lee; Jonas Kurniawan; Jacob Tureb; Zhongzhu Guo; Jangyeol Yoon; Sung Il Park; Sang Yun Bang; Yoonho Nam; Marie C. Walicki; Vijay K. Samineni; Aaron D. Mickle; Kunhyuk Lee; Seung Yun Heo; Jordan G. McCall; Taisong Pan; Liang Wang; Xue Feng; Tae il Kim; Jong Kyu Kim; Yuhang Li; Yonggang Huang; Robert W. Gereau; Jeong Sook Ha; Michael R. Bruchas; John A. Rogers

doi:10.1016/j.neuron.2016.12.031

Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics

Gunchul Shin, Adrian M. Gomez, Ream Al-Hasani, Yu Ra Jeong, Jeonghyun Kim, Zhaoqian Xie, Anthony Banks, Seung Min Lee, Sang Youn Han, Chul Jong Yoo, Jong Lam Lee, Seung Hee Lee, Jonas Kurniawan, Jacob Tureb, Zhongzhu Guo, Jangyeol Yoon, Sung Il Park, Sang Yun Bang, Yoonho Nam, Marie C. WalickiVijay K. Samineni, Aaron D. Mickle, Kunhyuk Lee, Seung Yun Heo, Jordan G. McCall, Taisong Pan, Liang Wang, Xue Feng, Tae il Kim, Jong Kyu Kim, Yuhang Li, Yonggang Huang, Robert W. Gereau, Jeong Sook Ha, Michael R. Bruchas, John A. Rogers

Department of Chemical and Biological Engineering

Research output: Contribution to journal › Article › peer-review

284 Citations (Scopus)

Abstract

In vivo optogenetics provides unique, powerful capabilities in the dissection of neural circuits implicated in neuropsychiatric disorders. Conventional hardware for such studies, however, physically tethers the experimental animal to an external light source, limiting the range of possible experiments. Emerging wireless options offer important capabilities that avoid some of these limitations, but the current size, bulk, weight, and wireless area of coverage is often disadvantageous. Here, we present a simple but powerful setup based on wireless, near-field power transfer and miniaturized, thin, flexible optoelectronic implants, for complete optical control in a variety of behavioral paradigms. The devices combine subdermal magnetic coil antennas connected to microscale, injectable light-emitting diodes (LEDs), with the ability to operate at wavelengths ranging from UV to blue, green-yellow, and red. An external loop antenna allows robust, straightforward application in a multitude of behavioral apparatuses. The result is a readily mass-producible, user-friendly technology with broad potential for optogenetics applications.

Original language	English
Pages (from-to)	509-521.e3
Journal	Neuron
Volume	93
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2016.12.031
Publication status	Published - 2017 Feb 8

Bibliographical note

Funding Information:
This work was supported by an NIH Director's Transformative Research Award (NS081707 to J.A.R., R.W.G., and M.R.B.). This work was also supported by the EUREKA Fund (DA037152, DA033396; supplement to A.M.G.) and an K99/R00 Pathway to Independence Award (DA038725 to R.A.-H.). Y.R.J. and J.S.H. were supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (grant NRF-2016R1A2A1A05004935), and J.S.H. also thanks the KU-KIST graduate school program of Korea University. Z.X. and X.F. acknowledge support from the National Basic Research Program of China (grant 2015CB351900) and the National Natural Science Foundation of China (grants 11402134 and 11320101001). Y.H. acknowledges the support from NSF (grants DMR-1121262, CMMI-1300846, and CMMI-1400169) and the NIH (grant R01EB019337). A.D.M. was supported by a McDonnell Center for Cellular and Molecular Neurobiology Postdoctoral Fellowship, and V.K.S. was supported by the Indian American Urological Association/Kailash Kedia, MD Research Scholar Fund. We would also like to thank Karl Deisseroth (Stanford) for sharing ChR2 with us, and Ed Boyden (MIT) for Chrimson with us.

Publisher Copyright:
© 2017 Elsevier Inc.

Keywords

ChR2
Chrimson
LED
NAc
VTA
dopamine
near-field communication
optogenetics
reward
wireless

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neuron.2016.12.031

Cite this

Shin, G., Gomez, A. M., Al-Hasani, R., Jeong, Y. R., Kim, J., Xie, Z., Banks, A., Lee, S. M., Han, S. Y., Yoo, C. J., Lee, J. L., Lee, S. H., Kurniawan, J., Tureb, J., Guo, Z., Yoon, J., Park, S. I., Bang, S. Y., Nam, Y., ... Rogers, J. A. (2017). Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics. Neuron, 93(3), 509-521.e3. https://doi.org/10.1016/j.neuron.2016.12.031

Shin, G, Gomez, AM, Al-Hasani, R, Jeong, YR, Kim, J, Xie, Z, Banks, A, Lee, SM, Han, SY, Yoo, CJ, Lee, JL, Lee, SH, Kurniawan, J, Tureb, J, Guo, Z, Yoon, J, Park, SI, Bang, SY, Nam, Y, Walicki, MC, Samineni, VK, Mickle, AD, Lee, K, Heo, SY, McCall, JG, Pan, T, Wang, L, Feng, X, Kim, TI, Kim, JK, Li, Y, Huang, Y, Gereau, RW, Ha, JS, Bruchas, MR & Rogers, JA 2017, 'Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics', Neuron, vol. 93, no. 3, pp. 509-521.e3. https://doi.org/10.1016/j.neuron.2016.12.031

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abstract = "In vivo optogenetics provides unique, powerful capabilities in the dissection of neural circuits implicated in neuropsychiatric disorders. Conventional hardware for such studies, however, physically tethers the experimental animal to an external light source, limiting the range of possible experiments. Emerging wireless options offer important capabilities that avoid some of these limitations, but the current size, bulk, weight, and wireless area of coverage is often disadvantageous. Here, we present a simple but powerful setup based on wireless, near-field power transfer and miniaturized, thin, flexible optoelectronic implants, for complete optical control in a variety of behavioral paradigms. The devices combine subdermal magnetic coil antennas connected to microscale, injectable light-emitting diodes (LEDs), with the ability to operate at wavelengths ranging from UV to blue, green-yellow, and red. An external loop antenna allows robust, straightforward application in a multitude of behavioral apparatuses. The result is a readily mass-producible, user-friendly technology with broad potential for optogenetics applications.",

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author = "Gunchul Shin and Gomez, {Adrian M.} and Ream Al-Hasani and Jeong, {Yu Ra} and Jeonghyun Kim and Zhaoqian Xie and Anthony Banks and Lee, {Seung Min} and Han, {Sang Youn} and Yoo, {Chul Jong} and Lee, {Jong Lam} and Lee, {Seung Hee} and Jonas Kurniawan and Jacob Tureb and Zhongzhu Guo and Jangyeol Yoon and Park, {Sung Il} and Bang, {Sang Yun} and Yoonho Nam and Walicki, {Marie C.} and Samineni, {Vijay K.} and Mickle, {Aaron D.} and Kunhyuk Lee and Heo, {Seung Yun} and McCall, {Jordan G.} and Taisong Pan and Liang Wang and Xue Feng and Kim, {Tae il} and Kim, {Jong Kyu} and Yuhang Li and Yonggang Huang and Gereau, {Robert W.} and Ha, {Jeong Sook} and Bruchas, {Michael R.} and Rogers, {John A.}",

note = "Funding Information: This work was supported by an NIH Director's Transformative Research Award (NS081707 to J.A.R., R.W.G., and M.R.B.). This work was also supported by the EUREKA Fund (DA037152, DA033396; supplement to A.M.G.) and an K99/R00 Pathway to Independence Award (DA038725 to R.A.-H.). Y.R.J. and J.S.H. were supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (grant NRF-2016R1A2A1A05004935), and J.S.H. also thanks the KU-KIST graduate school program of Korea University. Z.X. and X.F. acknowledge support from the National Basic Research Program of China (grant 2015CB351900) and the National Natural Science Foundation of China (grants 11402134 and 11320101001). Y.H. acknowledges the support from NSF (grants DMR-1121262, CMMI-1300846, and CMMI-1400169) and the NIH (grant R01EB019337). A.D.M. was supported by a McDonnell Center for Cellular and Molecular Neurobiology Postdoctoral Fellowship, and V.K.S. was supported by the Indian American Urological Association/Kailash Kedia, MD Research Scholar Fund. We would also like to thank Karl Deisseroth (Stanford) for sharing ChR2 with us, and Ed Boyden (MIT) for Chrimson with us. Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

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AU - Gomez, Adrian M.

AU - Al-Hasani, Ream

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AU - Kim, Jeonghyun

AU - Xie, Zhaoqian

AU - Banks, Anthony

AU - Lee, Seung Min

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AU - Samineni, Vijay K.

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AU - Heo, Seung Yun

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AU - Wang, Liang

AU - Feng, Xue

AU - Kim, Tae il

AU - Kim, Jong Kyu

AU - Li, Yuhang

AU - Huang, Yonggang

AU - Gereau, Robert W.

AU - Ha, Jeong Sook

AU - Bruchas, Michael R.

AU - Rogers, John A.

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Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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