Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing

Canran Wang; Xing Jiang; Han Jun Kim; Shiming Zhang; Xingwu Zhou; Yi Chen; Haonan Ling; Yumeng Xue; Zhaowei Chen; Moyuan Qu; Li Ren; Jixiang Zhu; Alberto Libanori; Yangzhi Zhu; Heemin Kang; Samad Ahadian; Mehmet R. Dokmeci; Peyman Servati; Ximin He; Zhen Gu; Wujin Sun; Ali Khademhosseini

doi:10.1016/j.biomaterials.2022.121479

Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing

Canran Wang, Xing Jiang, Han Jun Kim, Shiming Zhang, Xingwu Zhou, Yi Chen, Haonan Ling, Yumeng Xue, Zhaowei Chen, Moyuan Qu, Li Ren, Jixiang Zhu, Alberto Libanori, Yangzhi Zhu, Heemin Kang, Samad Ahadian, Mehmet R. Dokmeci, Peyman Servati, Ximin He, Zhen GuWujin Sun, Ali Khademhosseini

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Electrical stimulation can facilitate wound healing with high efficiency and limited side effects. However, current electrical stimulation devices have poor conformability with wounds due to their bulky nature and the rigidity of electrodes utilized. Here, a flexible electrical patch (ePatch) made with conductive hydrogel as electrodes to improve wound management was reported. The conductive hydrogel was synthesized using silver nanowire (AgNW) and methacrylated alginate (MAA), with the former chosen as the electrode material considering its antibacterial properties, and the latter used due to its clinical suitability in wound healing. The composition of the hydrogel was optimized to enable printing on medical-grade patches for personalized wound treatment. The ePatch was shown to promote re-epithelization, enhance angiogenesis, mediate immune response, and prevent infection development in the wound microenvironment. In vitro studies indicated an elevated secretion of growth factors with enhanced cell proliferation and migration ability in response to electrical stimulation. An in vivo study in the Sprague-Dawley rat model revealed a rapid wound closure within 7 days compared to 20 days of usual healing process in rodents.

Original language	English
Article number	121479
Journal	Biomaterials
Volume	285
DOIs	https://doi.org/10.1016/j.biomaterials.2022.121479
Publication status	Published - 2022 Jun

Keywords

Antibacteria
Conductive hydrogel
Electrical stimulation
Wearable device
Wound healing

ASJC Scopus subject areas

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

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10.1016/j.biomaterials.2022.121479

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Wang, C., Jiang, X., Kim, H. J., Zhang, S., Zhou, X., Chen, Y., Ling, H., Xue, Y., Chen, Z., Qu, M., Ren, L., Zhu, J., Libanori, A., Zhu, Y., Kang, H., Ahadian, S., Dokmeci, M. R., Servati, P., He, X., ... Khademhosseini, A. (2022). Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing. Biomaterials, 285, Article 121479. https://doi.org/10.1016/j.biomaterials.2022.121479

Wang, C, Jiang, X, Kim, HJ, Zhang, S, Zhou, X, Chen, Y, Ling, H, Xue, Y, Chen, Z, Qu, M, Ren, L, Zhu, J, Libanori, A, Zhu, Y, Kang, H, Ahadian, S, Dokmeci, MR, Servati, P, He, X, Gu, Z, Sun, W & Khademhosseini, A 2022, 'Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing', Biomaterials, vol. 285, 121479. https://doi.org/10.1016/j.biomaterials.2022.121479

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title = "Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing",

abstract = "Electrical stimulation can facilitate wound healing with high efficiency and limited side effects. However, current electrical stimulation devices have poor conformability with wounds due to their bulky nature and the rigidity of electrodes utilized. Here, a flexible electrical patch (ePatch) made with conductive hydrogel as electrodes to improve wound management was reported. The conductive hydrogel was synthesized using silver nanowire (AgNW) and methacrylated alginate (MAA), with the former chosen as the electrode material considering its antibacterial properties, and the latter used due to its clinical suitability in wound healing. The composition of the hydrogel was optimized to enable printing on medical-grade patches for personalized wound treatment. The ePatch was shown to promote re-epithelization, enhance angiogenesis, mediate immune response, and prevent infection development in the wound microenvironment. In vitro studies indicated an elevated secretion of growth factors with enhanced cell proliferation and migration ability in response to electrical stimulation. An in vivo study in the Sprague-Dawley rat model revealed a rapid wound closure within 7 days compared to 20 days of usual healing process in rodents.",

keywords = "Antibacteria, Conductive hydrogel, Electrical stimulation, Wearable device, Wound healing",

author = "Canran Wang and Xing Jiang and Kim, {Han Jun} and Shiming Zhang and Xingwu Zhou and Yi Chen and Haonan Ling and Yumeng Xue and Zhaowei Chen and Moyuan Qu and Li Ren and Jixiang Zhu and Alberto Libanori and Yangzhi Zhu and Heemin Kang and Samad Ahadian and Dokmeci, {Mehmet R.} and Peyman Servati and Ximin He and Zhen Gu and Wujin Sun and Ali Khademhosseini",

note = "Funding Information: The authors acknowledge funding from the National Institutes of Health ( EB024403 , EB023052 , GM126831 , and HL140618 ). Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = jun,

doi = "10.1016/j.biomaterials.2022.121479",

language = "English",

volume = "285",

journal = "Biomaterials",

issn = "0142-9612",

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T1 - Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing

AU - Wang, Canran

AU - Jiang, Xing

AU - Kim, Han Jun

AU - Zhang, Shiming

AU - Zhou, Xingwu

AU - Chen, Yi

AU - Ling, Haonan

AU - Xue, Yumeng

AU - Chen, Zhaowei

AU - Qu, Moyuan

AU - Ren, Li

AU - Zhu, Jixiang

AU - Libanori, Alberto

AU - Zhu, Yangzhi

AU - Kang, Heemin

AU - Ahadian, Samad

AU - Dokmeci, Mehmet R.

AU - Servati, Peyman

AU - He, Ximin

AU - Gu, Zhen

AU - Sun, Wujin

AU - Khademhosseini, Ali

PY - 2022/6

Y1 - 2022/6

N2 - Electrical stimulation can facilitate wound healing with high efficiency and limited side effects. However, current electrical stimulation devices have poor conformability with wounds due to their bulky nature and the rigidity of electrodes utilized. Here, a flexible electrical patch (ePatch) made with conductive hydrogel as electrodes to improve wound management was reported. The conductive hydrogel was synthesized using silver nanowire (AgNW) and methacrylated alginate (MAA), with the former chosen as the electrode material considering its antibacterial properties, and the latter used due to its clinical suitability in wound healing. The composition of the hydrogel was optimized to enable printing on medical-grade patches for personalized wound treatment. The ePatch was shown to promote re-epithelization, enhance angiogenesis, mediate immune response, and prevent infection development in the wound microenvironment. In vitro studies indicated an elevated secretion of growth factors with enhanced cell proliferation and migration ability in response to electrical stimulation. An in vivo study in the Sprague-Dawley rat model revealed a rapid wound closure within 7 days compared to 20 days of usual healing process in rodents.

AB - Electrical stimulation can facilitate wound healing with high efficiency and limited side effects. However, current electrical stimulation devices have poor conformability with wounds due to their bulky nature and the rigidity of electrodes utilized. Here, a flexible electrical patch (ePatch) made with conductive hydrogel as electrodes to improve wound management was reported. The conductive hydrogel was synthesized using silver nanowire (AgNW) and methacrylated alginate (MAA), with the former chosen as the electrode material considering its antibacterial properties, and the latter used due to its clinical suitability in wound healing. The composition of the hydrogel was optimized to enable printing on medical-grade patches for personalized wound treatment. The ePatch was shown to promote re-epithelization, enhance angiogenesis, mediate immune response, and prevent infection development in the wound microenvironment. In vitro studies indicated an elevated secretion of growth factors with enhanced cell proliferation and migration ability in response to electrical stimulation. An in vivo study in the Sprague-Dawley rat model revealed a rapid wound closure within 7 days compared to 20 days of usual healing process in rodents.

KW - Antibacteria

KW - Conductive hydrogel

KW - Electrical stimulation

KW - Wearable device

KW - Wound healing

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DO - 10.1016/j.biomaterials.2022.121479

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SN - 0142-9612

VL - 285

JO - Biomaterials

JF - Biomaterials

M1 - 121479

ER -

Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing

Abstract

Keywords

ASJC Scopus subject areas

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