Flow reaction system for the synthesis of benzoylacetonitrile via the reaction of amides and acetonitrile

Joonyoung Kim, Myeong Seong Park, Sunwoo Lee, Kwang Ho Song

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Unactivated amides, such as N,N-dimethylbenzamide, react with acetonitrile in the presence of LiHMDS under flow reaction conditions to afford corresponding benzoylacetonitriles in good yields. The sequential flow reaction system is also applicable to the synthesis of benzoylacetonitrile from N-methylbenzamide.

Original languageEnglish
Article number154201
JournalTetrahedron Letters
Volume111
DOIs
Publication statusPublished - 2022 Nov 23

Bibliographical note

Funding Information:
This research was supported by the grant funded by the Korean government ( MSIT ) ( NRF-2021R1A2C1005169 ) and the Korea University . Spectral and HRMS data were obtained at the Korea Basic Science Institute, Gwangju center and Daegu center.

Funding Information:
This research was supported by the grant funded by the Korean government (MSIT) (NRF-2021R1A2C1005169) and the Korea University. Spectral and HRMS data were obtained at the Korea Basic Science Institute, Gwangju center and Daegu center.

Publisher Copyright:
© 2022 Elsevier Ltd

Keywords

  • Amide
  • Benzoylacetonitrile
  • C-N bond activation
  • Flow reaction
  • LiHMDS

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Flow reaction system for the synthesis of benzoylacetonitrile via the reaction of amides and acetonitrile'. Together they form a unique fingerprint.

Cite this