Fluorescence-Based Mono- and Multimodal Imaging for In Vivo Tracking of Mesenchymal Stem Cells

Wan Su Yun, Hanhee Cho, Seong Ik Jeon, Dong Kwon Lim, Kwangmeyung Kim

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

The advancement of stem cell therapy has offered transformative therapeutic outcomes for a wide array of diseases over the past decades. Consequently, stem cell tracking has become significant in revealing the mechanisms of action and ensuring safe and effective treatments. Fluorescence stands out as a promising choice for stem cell tracking due to its myriad advantages, including high resolution, real-time monitoring, and multi-fluorescence detection. Furthermore, combining fluorescence with other tracking modalities—such as bioluminescence imaging (BLI), positron emission tomography (PET), photoacoustic (PA), computed tomography (CT), and magnetic resonance (MR)—can address the limitations of single fluorescence detection. This review initially introduces stem cell tracking using fluorescence imaging, detailing various labeling strategies such as green fluorescence protein (GFP) tagging, fluorescence dye labeling, and nanoparticle uptake. Subsequently, we present several combinations of strategies for efficient and precise detection.

Original languageEnglish
Article number1787
JournalBiomolecules
Volume13
Issue number12
DOIs
Publication statusPublished - 2023 Dec

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

  • fluorescence imaging
  • in vivo cell imaging
  • multimodal imaging
  • stem cell tracking

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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